Clinical efficacy of NPWT combined with silver ion dressing in elderly male diabetic toe osteomyelitis and its effect on MMP 2,TMP 1 and VEGF
Objective To analyze the clinical efficacy of NPWT combined with silver ion dress-ing in the treatment of postoperative defects of DFO in elderly men and its effects on the levels of MMP2,TMP1 and VEGF.Methods Thirty elderly male patients with DFO postoperative defects admitted to the De-partment of Endocrinology,Wuhan Third Hospital from May 2021 to July 2022 were prospectively selected and randomly divided into control group (15 cases,silver ion dressing treatment) and combined group (15 cases,NPWT combined with silver ion dressing treatment).The wound infection,CRP,wound volume change,wound healing rate,wound healing time,toe amputation rate and the levels of MMP2,TMP1 and VEGF in wound tissue were compared between the two groups after 14 days of treatment.The recurrence and toe amputation of the two groups were observed after 3-6 months of follow-up.Results After 7 days and 14 days of treatment,the wound infection rate of the combined group was lower than that of the control group,and the difference was statistically significant (P<0.05).After 14 days of treatment,the CRP value and wound volume value of the combined group were lower than those of the control group,and the difference was statisti-cally significant (P<0.05).The wound healing rate in the combined group was 86.67％,which was higher than 40.00％ in the control group.2;the cutting rate of 6.67％ and the wound healing time of 65.53 days were lower than the control group,significant (P<0.05).There were significant differences in the time effect,inter-group effect and interaction effect of MMP2 and TMP1 between the two groups (P<0.05).With the prolonga-tion of treatment time,the expression of VEGF and TMP1 in the combined group increased,and the expres-sion of MMP2 decreased (P<0.05).The 3-month recurrence rate,recurrence toe amputation rate and 6-month toe amputation rate in the combined group were lower than those in the control group (P<0.05).However,there was no significant difference in the recurrence rate at 6 months (P>0.05).Conclusion The combination of NPWT and silver ion dressing in DFO can reduce the rate of DFO recurrence and amputation after 3 months.The molecular mechanism may be associated with the reduction of MMP 2 and increasing the expression of TMP 1 and VEGF.
Diabetic foot ulcerOosteomyelitisNPWT treatmentSilver ion dressing
万方数据
维普
