The relationship between 1q21 amplification,serum IL-21,lactate dehydrogenase and efficacy and prognosis of patients with multiple myeloma
Objective To explore the relationship between 1q21 amplification,serum IL-21,LDH and MM efficacy and prognosis.Methods A total of 162 MM patients admitted to the Hematology De-partment of Chuzhou First People's Hospital from October 2017 to June 2023 were selected.According to the efficacy criteria of MM,the patients were divided into an effective group of 113 cases and an ineffective group of 49 cases.Serum IL-21,LDH levels and 1q21 amplification positive rate were compared between the two groups.Spearman and kendall correlation coefficients were used to analyze the relationship between IL-21,LDH and 1q21 amplification and the efficacy of MM patients.Patients in remission were followed up until De-cember 2023,and were divided into good prognosis group (n=64) and poor prognosis group (n=98).The general data and relevant laboratory indicators of the two groups were compared,and the correlation between 1q21 amplification,serum IL-21 and LDH and the prognosis of MM patients was analyzed by multivariate Lo-gistic analysis.The predictive value of serum IL-21 and LDH combined detection in MM patients was evalu-ated by ROC.Results The levels of IL-21,LDH and the positive rate of 1q21 amplification in the ineffec-tive group were significantly higher than those in the effective group,with statistical significance (x2/t=11.953,11.116,39.329,all P<0.05).The efficacy of MM patients was negatively correlated with serum IL-21,LDH levels and 1q21 amplification positive rate (r=-0.613,-0.294,-0.572,all P<0.05).Multivariate regres-sion analysis showed that age>60,combined amyloidosis,1q21 amplification,elevated serum IL-21 and LDH expression levels were independent risk factors for the prognosis of MM patients (P<0.05).ROC curve showed that the ROC areas of serum IL-21 and LDH and their combined detection were 0.785,0.781 and 0.849,respectively (all P<0.05).Conclusion The amplification of 1q21 and the high expression of serum IL-21 and LDH may affect the efficacy of MM patients,and the combined detection of serum IL-21 and LDH has a high value in the prognosis assessment of MM patients.
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