Correlation between PDK1 expression in peripheral blood and inflammatory response in patients with chronic heart failure and its clinical significance
Objective To investigate the correlation between the expression of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in peripheral blood and inflammatory response in patients with chronic heart failure (CHF) and its clinical significance.Methods A total of 180 patients with CHF admitted to Lansh-eng Brain Hospital in Chengdu from March 2022 to March 2024 were selected for the CHF group.This group was further divided into mild heart failure with New York Heart Association (NYHA) grade Ⅱ and severe heart failure with grade Ⅲ to Ⅳ.Additionally.110 healthy individuals who underwent physical examinations at our hospital during the same period were included as the control group.The mRNA expression level of PDK1 in pe-ripheral blood and the levels of serum C-reactive protein (CRP),soluble urokinase-type plasminogen activator receptor (suPAR),interleukin-6 (IL-6) and interleukin-8 (IL-8) in serum were measured.Statistical analysis using t-test was conducted to compare the differences in PDK1,CRP,suPAR,IL-6 and IL-8 among all groups,The Pearson test was used to analyze correlations,and ROC curves were generated to assess the diagnostic value of each indicator in determining the condition of CHF.Results The mRNA expression level of PDK1 in the pe-ripheral blood of the CHF group was lower than that of the control group (t=12.356,P<0.05),and the levels of CRP,suPAR,IL-6 and IL-8 in serum were higher than those in the control group,with statistical significance (t=12.193,19.347,18.742,13.044,P<0.05).The mRNA expression level of PDK1 in the peripheral blood of pa-tients with severe heart failure in the CHF group was lower than that of patients with mild heart failure (t=9.925,P<0.05),and the serum levels of CRP,suPAR,IL-6,and IL-8 were higher than those of patients with mild heart failure,with statistical significance (t=5.444,5.647,6.312,8.015,P<0.05).The mRNA expression level of PDK1 in the peripheral blood of the CHF group was negatively correlated with the levels of CRP,suPAR,IL-6,and IL-8 in serum (P<0.05).Conclusion The expression of PDK1 in the peripheral blood of CHF patients is decreased,which is related to the worsening of heart failure and the activation of the inflammatory response.
Chronic heart failure3-phosphoinositide-dependent protein kinase-1Inflammatory response
万方数据
维普
