Hydroxysteroid dehydrogenase is a member of the aldokeone reductase and short chain dehydrogenase-reductase superfamily,which plays a crucial role in the normal function of steroid hormones in the body.HSD17B6 is one of the hydroxy steroid dehydrogenases,mainly involved in the metabolism and bio-synthesis of androgens in vivo.It produces the high affinity ligand of estrogen receptor β,which may affect the metabolism of glucose and lipids in the body,leading to endocrine and reproductive system disorders and dis-eases.Abnormal expression of HSD17B6 is also related to the immune function of the body and can be involved in the occurrence and development of tumors.As a potential biomarker,HSD17B6 can be used for the diagnosis and evaluation of tumors,providing reference information for drugs or targeted therapies.Although the precise mechanism of its effect on disease remains unclear,the loss of function of HSD17B may cause varying degrees of damage to the body.This article reviews the role of HSD17B6 in metabolic diseases and tumors.
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