The Human Genome Project benefited greatly from the emergence of Sanger DNA se⁃quencing technology,allowing for the creation of a draft of the human reference genome.With advancements in sequencing technology,the human reference genome has been continuously updated and refined,with the most recent version being GRCh38.p14.The Telomere⁃to⁃Telomere(T2T)consortium used large⁃scale parallel sequencing and single⁃molecule long⁃read sequencing technology to sequence the human haploid chromo⁃somes,providing a new reference point.The publication of the complete diploid genome of a Chinese indi⁃vidual(CN1,YAO)signifies a milestone in the development of the reference genome.This article primarily focuses on the historical progression of the human reference genome,the status and analysis of various refer⁃ence genome versions,and potential future development trends.
维普
万方数据