Relationship between serum ICAM?1 and FSTL?1 levels and ventricular remodeling in elderly patients with chronic heart failure
Objective To investigate the relationship between serum intercellular adhesion mol⁃ecule⁃1(ICAM⁃1)and follistatin⁃like protein 1(FSTL⁃1)levels and ventricular remodeling(VR)in elderly pa⁃tients with chronic heart failure(CHF).Methods A total of 256 elderly patients with CHF admitted to 964 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from March 2020 to March 2023 were included in the study.Patients with CHF were divided into the VR group and the non⁃VR group.Clinical data and serum ICAM⁃1 and FSTL⁃1 expression were compared between the two groups.The relationship be⁃tween clinical data,serum ICAM⁃1 and FSTL⁃1 and the occurrence of VR in elderly patients with CHF was ana⁃lyzed.The predictive value of serum ICAM⁃1 and FSTL⁃1 for VR in elderly patients with CHF was evaluated.Results Among the 256 patients with CHF,the incidence of VR was 30.08％.The proportion of male pa⁃tients,age,the proportion of patients with hypertension,and serum levels of ICAM⁃1 and FSTL⁃1 in the VR group were significantly higher than those in the non⁃VR group,and the differences were statistically significant(P<0.05).Logistic regression analysis found that male,advanced age,hypertension,and high serum ICAM⁃1 and FSTL⁃1 levels were risk factors for VR in elderly patients with CHF(P<0.05).The area under the receiver operating characteristic(ROC)curve(AUC)of serum ICAM⁃1 combined with FSTL⁃1 for predicting the occur⁃rence of VR in patients with CHF was 0.900,larger than that of separate prediction(P<0.05).Conclusion ICAM⁃1 and FSTL⁃1 are significantly associated with the occurrence of VR in elderly patients with CHF.The combined detection of the two can effectively predict the occurrence of VR in elderly patients with CHF.
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