Correlation of high?frequency ultrasound manifestations of synovial lesions in rheumatoid arthritis with Anti?CCP,ESR and CRP
Objective To analyze the correlation between high⁃frequency ultrasound manifesta⁃tions of synovial lesions in rheumatoid arthritis(RA)and anti⁃cyclic citrullinated peptide antibody(Anti⁃CCP),erythrocyte sedimentation rate(ESR)and C⁃reactive protein(CRP),to provide a more accurate and scientific basis for the early diagnosis and treatment of the disease.Methods From January 2020 to March 2023,65 pa⁃tients with RA before treatment(RA group)were selected from the Department of Rheumatology and Immunol⁃ogy,Daqing Longnan Hospital,and 55 healthy subjects(control group)who underwent physical examination in the physical examination center of our hospital during the same period were selected.The high⁃frequency ul⁃trasound findings,suprapatellar bursa fluid thickness,synovial thickness,synovial artery RI and laboratory in⁃dicators(Anti⁃CCP,ESR and CRP levels)were compared between the two groups.The RA group was divided into a positive and a negative group based on the positive criteria of Anti⁃CCP,ESR and CRP.The suprapatellar bursa fluid thickness,synovial thickness and synovial artery RI were compared between the Anti⁃ccp,ESR and CRP positive and negative groups.Pearson was used to analyze the correlation between high⁃frequency ultra⁃sound manifestations of synovial lesions and Anti⁃CCP,ESR and CRP.Results In the control group,the knee effusion was 4 mm less and more symmetrical,especially in the inner and outer recesses.The synovium of the control group was difficult to distinguish,while the synovium of the RA group was thickened,low echo,had a clear boundary,rough surface,and villi.Color Doppler ultrasound showed that 81.53％of the knee synovium in the RA group had obvious blood flow signals,mostly grade Ⅱ and Ⅲ.The thickness of the suprapatellar bursa fluid,synovial thickness,Anti⁃CCP,ESR and CRP levels in the RA group were higher than those in the control group.Additionally,the synovial artery RI was lower than that in the control group,and these differences were statistically significant(P<0.05).The levels of suprapatellar bursa fluid thickness and synovial thickness in the Anti⁃CCP,ESR and CRP positive groups were significantly higher than those in the negative group,and the RI of synovial artery was lower than that in the negative group,the differences were statistically significant(P<0.05).The suprapatellar bursa fluid thickness and synovial thickness were positively correlated with Anti⁃CCP,ESR and CRP levels(P<0.05).Synovial artery RI was negatively correlated with Anti⁃CCP,ESR and CRP lev⁃els(P<0.05).Conclusion High⁃frequency ultrasound can clearly observe the synovial lesions of RA patients and has a significant correlation with laboratory indicators such as Anti⁃CCP,ESR and CRP.It can provide a strong reference for the clinical diagnosis of RA patients with synovial lesions,which is conducive to the devel⁃opment of more targeted treatment measures.
RASynovial lesionsHigh frequency ultrasoundAnti-CCPESRCRP
万方数据
