The changes of IL?10,IL?8 and SP levels after PTED treatment of LDH and their relationship with neurological function recovery
Objective To investigate the changes of interleukin⁃10(IL⁃10),interleukin⁃8(IL⁃8)and substance P(SP)levels after percutaneous transforaminal endoscopic discectomy(PTED)in the treatment of lumbar disc herniation(LDH)and their relationship with the recovery of neurological function.Methods A total of 131 patients with LDH admitted to Baoding First Central Hospital from January 2022 to January 2024 were selected and divided into a control group[traditional fenestration decompression nucleus pulposus removal(ODD),n=65)]and an experimental group(PTED,n=66)based on different treatment methods.The periop⁃erative indexes,lumbar motion function(lumbar flexion,extension,left flexion and right flexion),pain de⁃gree[visual analogue scale(VAS)],spinal function[lumbar Oswestry dysfunction index(ODI)],biome⁃chanical properties of low back muscle[lumbar dorsiflexion and extension ratio(F/E),average extension power(AP),peak torque(PT)],laboratory indicators(IL⁃10,IL⁃8,and SP levels)and incidence of compli⁃cations were compared between the two groups before and 3 months after operation.Results The experimental group had shorter surgery time,hospitalization time,time out of bed and incision length and less intraoperative bleeding than those of the control group,with statistically significant differences(P<0.05).The lumbar flexion,extension,left flexion and right flexion of the two groups increased at 3 months after operation,and the experi⁃mental group was higher than the control group,the difference was statistically significant(P<0.05).The VAS and ODI scores of the two groups decreased at 3 months after operation,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05).The AP and PT of the two groups in⁃creased at 3 months after operation,and the experimental group was higher than the control group.The F/E of the two groups decreased at 3 months after operation,and the experimental group was lower than the control group.The difference was statistically significant(P<0.05).The levels of IL⁃10,IL⁃8,and SP in the two groups de⁃creased at 3 days after operation,and those in the experimental group were lower than the control group,the dif⁃ferences were statistically significant(P<0.05).The total incidence of complications in the experimental group(7.57％)was significantly lower than that in the control group(20.00％),the difference was statistically signifi⁃cant(P<0.05).Pearson correlation analysis showed that IL⁃8 and SP levels were positively correlated with ODI score after PTED treatment of lumbar disc herniation,and IL⁃10 level was negatively correlated with ODI score(P<0.05).Conclusion Compared to ODD,PTED is more effective in the treatment of LDH,which can effec⁃tively promote the recovery of neurological function,reducing the levels of serum IL⁃10,IL⁃8 and SP.
PTEDLumbar disc herniationIL-10IL-8SPNeurological function
万方数据
