目的 分析复方α⁃酮酸联合盐酸贝那普利对糖尿病肾病(DKD)患者肾功能及血清炎症因子的影响.方法 选取2020年2月至2022年4月海口市第四人民医院收治的82例DKD患者,随机分为观察组、对照组各41例,在常规治疗基础上,对照组予以盐酸贝那普利治疗2个月,观察组采用复方α⁃酮酸片联合盐酸贝那普利治疗2个月.比较两组治疗效果、血糖参数、肾功能和炎症因子[白介素⁃6(IL⁃6)、超敏⁃C反应蛋白(hs⁃CRP)]水平变化,记录两组不良反应.结果 观察组治疗有效率为90.24％,高于对照组的 70.73％(P<0.05);治疗后观察组FPG、2hPG、HbA1c及 24 h UAER、BUN、Scr均低于对照组,eGFR高于对照组(P<0.05);治疗后观察组血清IL⁃6、hs⁃CRP水平低于对照组(P<0.05);两组不良反应发生率分别为 12.20％、7.32％(P>0.05).结论 复方α⁃酮酸联合盐酸贝那普利治疗DKD疗效较好,可明显改善患者血糖水平及肾功能,降低炎症反应.
Effect of compound α?ketoacid combined with benazepril hydrochloride on kidney func?tion and serum inflammatory factors in patients with DKD
Objective To analyze the effect of compound α⁃ketoacid combined with benazepril hy⁃drochloride on kidney function and serum inflammatory factors in patients with DKD.Methods A total of 82 pa⁃tients with DKD admitted to the Fourth People's Hospital of Haikou from February 2020 to April 2022 were se⁃lected,and randomly divided into the observation group and the control group,with 41 patients in each group.Based on conventional treatment,the control group was treated with benazepril hydrochloride for 2 months,while the observation group was treated with compound α⁃ketoacid tablets combined with benazepril hydrochloride for 2 months.The two groups were compared on clinical efficacy and changes in the levels of blood glucose param⁃eters,renal function and inflammatory factors(IL⁃6 and hs⁃CRP).Adverse reactions were recorded.Results The treatment response rate in the observation group(90.24％)was higher than that in the control group(70.73％)(P<0.05).After treatment,FPG,2hPG,HbA1c,24h UAER,BUN,and Scr were lower,and eGFR was higher in the observation group(P<0.05).Serum IL⁃6 and hs⁃CRP levels in the observation group were lower(P<0.05).The incidence rates of adverse reactions in the two groups were 12.20％and 7.32％(P>0.05).Conclusion Com⁃pound α⁃ketoacid combined with benazepril hydrochloride is effective in the treatment of DKD,which can signifi⁃cantly improve the patients'blood glucose levels and kidney function,and reduce inflammatory reactions.
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