Therapeutic effect of liraglutide injection combined with dapagliflozin on type 2 diabetic nephropathy and its effect on creatinine,urea nitrogen and ACR levels
Objective To investigate the effect of liraglutide injection combined with dapagliflozin on the treatment of type 2 diabetic nephropathy(T2DN)and its effect on serum creatinine(Scr),urea nitrogen(BUN)and urinary albumin creatinine ratio(ACR).Methods Retrospectively,100 cases of T2DN patients ad⁃mitted to Lixin County People's Hospital from July 2021 to January 2024 were selected.Based on the treatment regimen,patients were divided into two groups:the control group(49 cases,receiving liraglutide treatment)and the experimental group(51 patients,receiving both liraglutide and dapagliflozin treatment).The clinical effective⁃ness,incidence of adverse reactions,renal function,inflammatory factors,and blood glucose insulin indices were compared between the two patient groups after a three⁃month course of treatment.Results The overall clinical ef⁃ficacy rate in the experimental group was significantly higher than that in the control group(P<0.05).After the in⁃tervention,the levels of glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA⁃IR),and 2h post⁃prandial glucose(2hPG),and inflammatory indicators such as procalcitonin(PCT),interleukin⁃17(IL⁃17),and tumor necrosis factor⁃alpha(TNF⁃α)in the experimental group were lower than those in the control group(P<0.05),as well as higher levels of pancreatic β⁃cell function index(HOMA⁃β)and the difference was statistically significant(P<0.05).The main adverse reactions of the two groups were gastrointestinal discomfort,hypoglyce⁃mia,loss of appetite and rash.There was no significant difference in the total incidence of adverse reactions be⁃tween the two groups(P>0.05).Conclusion The combination of liraglutide injection and dapagliflozin has shown significant efficacy in the treatment of T2DN.It effectively controls blood glucose levels,improves pan⁃creatic islet function,regulates Scr,BUN,and ACR levels,and reduces inflammatory response.
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