Diagnostic value of transperineal pelvic floor ultrasound combined with serum TIMP?1 and MMP?1 levels in female stress urinary incontinence
Objective To investigate the diagnostic value of perineal pelvic floor ultrasound com⁃bined with serum metalloproteinase⁃1(TIMP⁃1)and matrix metalloproteinase⁃1(MMP⁃1)levels in women with stress urinary incontinence.Methods A total of 134 patients with perineal pelvic floor ultrasound admit⁃ted to the gynecology department at Zhengzhou Central Hospital Affiliated to Zhengzhou University from Janu⁃ary 2022 to December 2023 were retrospectively selected.They were divided into the study group(71 cases)and the control group(63 cases)based on whether there was stress incontinence.The general data,perineal pel⁃vic floor ultrasound parameters(bladder neck mobility(BND),anal flexor hiatus area(LHA),urethral inclina⁃tion Angle(UTA),urethral rotation Angle(URA),vesicourethral posterior Angle(PVUA))of the two groups were compared,and serum MMP⁃1 and TIMP⁃1 levels were compared between the two groups.Multi⁃variate logistic regression was used to analyze the factors affecting the occurrence of stress urinary incontinence,and the value of perineal pelvic floor ultrasound combined with serum TIMP⁃1 and MMP⁃1 levels in the diagno⁃sis of female stress urinary incontinence was evaluated by subject work characteristic curve.Results The pro⁃portion of patients with normal birth and delivery times>1 in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of BND,LHA,UTA,URA,PVUA,and MMP⁃1 in the study group were higher than those in the control group,while the expression level of TIMP⁃1 in the study group was lower than that in the control group,with statistical significance(P<0.05).Mul⁃tiple logistic regression analysis showed that natural delivery,number of deliveries>1,BND,LHA,serum MMP⁃1,TIMP⁃1 were independent factors affecting the occurrence of female stress incontinence(P<0.05).Ac⁃cording to the ROC curve,the AUC of BND,LHA,TIMP⁃1,and MMP⁃1 combined in predicting the occurrence of female stress urinary incontinence was 0.963,which was higher than that of single detection(P<0.05).Conclu⁃sion Perineal pelvic floor ultrasound parameters,serum MMP⁃1,and TIMP⁃1 levels are closely related to the oc⁃currence of female stress incontinence.BND,LHA,serum MMP⁃1,and TIMP⁃1 are all independent influencing factors for the disease.The combined detection of the four has good diagnostic value in evaluating the occurrence of female stress incontinence.
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