Changes and prognostic value of IL?1β,TNF?α and IL?10 before and after high voltage pulse RF therapy in PHN
Objective To investigate the changes of serum interleukin⁃1β(IL⁃1β),tumor necrosis factor⁃α(TNF⁃α)and interleukin⁃10(IL⁃10)before and after treatment of high voltage pulsed radio frequency(PRF)in postherpetic neuralgia(PHN).Methods From June 2020 to June 2023,a study was conducted at Sanmenxia City Central Hospital involving 142 patients with PHN who received PRF treatment.The study com⁃pared the serum levels of IL⁃1β,TNF⁃α,and IL⁃10 in PHN patients before and after treatment.After discharge,the patients were followed up for 6 months and divided into a good prognosis group(n=98)and a poor progno⁃sis group(n=44).The basic data and laboratory indicators of these two groups were compared,and the correla⁃tion between changes in serum IL⁃1β,TNF⁃α,and IL⁃10 levels before and after treatment and the prognosis of PHN patients was analyzed using single and multiple logistic analysis.A receiver operating characteristic curve(ROC)was created to assess the predictive value of combined detection of the three tests on the prognosis of PHN patients.Results The levels of IL⁃1β and TNF⁃α in PHN patients after PRF treatment were lower than be⁃fore treatment,with statistical significance(P<0.05),while the levels of IL⁃10 in PHN patients after PRF treat⁃ment were higher than before treatment,with statistical significance(P<0.05).There were significant differ⁃ences between the two groups in the course of disease,skin area,whether diabetes mellitus was combined,whether analgesic drugs were used,and serum levels of IL⁃1β,TNF⁃α,and IL⁃10 before and after treatment(P<0.05).The results of multi⁃factor analysis showed that the combination of diabetes mellitus and the reduc⁃tion of IL⁃1β,TNF⁃α,and IL⁃10 difference before and after treatment were independent risk factors affecting the prognosis of PHN patients(P<0.05).The ROC curve showed that the area under the curve of IL⁃1β,TNF⁃α,and IL⁃10 combined detection was 0.881,which was better than that of individual detection(P<0.05).Conclusion After PRF treatment,serum levels of IL⁃1β,TNF⁃α,and IL⁃10 in PHN patients were signifi⁃cantly improved.The difference in levels of these three cytokines before and after treatment proved to be highly valuable for prognostic risk assessment in PHN patients.
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