首页|哌拉西林钠舒巴坦联合乙酰半胱氨酸雾化吸入治疗急性支气管炎的疗效分析

哌拉西林钠舒巴坦联合乙酰半胱氨酸雾化吸入治疗急性支气管炎的疗效分析

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目的 探讨哌拉西林钠舒巴坦静脉滴注联合乙酰半胱氨酸雾化吸入治疗急性支气管炎的疗效及对外周血免疫球蛋白、血小板/淋巴细胞比值(PLR)、血清淀粉样蛋白(SAA)的影响.方法 选取2021年2月至2024年2月期间于南京医科大学第四附属医院儿科接受治疗的急性支气管炎患儿202例,根据随机数字表法分为对照组(n=101,采用乙酰半胱氨酸雾化吸入治疗)和研究组(n=101,采用哌拉西林钠舒巴坦静脉滴注联合乙酰半胱氨酸雾化吸入治疗).比较两组疗效、细菌清除率、免疫球蛋白、PLR和SAA水平.结果 研究组的治疗总有效率为92.08%,高于对照组的78.22%,差异有统计学意义(P<0.05);研究组细菌清除率为 94.06%,较对照组的 81.19%高,差异有统计学意义(P<0.05);治疗后两组免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平均上升,且研究组上升幅度大于对照组,差异有统计学意义(P<0.05);治疗后两组PLR、SAA水平均下降,且研究组下降幅度大于对照组,差异有统计学意义(P<0.05).结论 哌拉西林钠舒巴坦联合乙酰半胱氨酸雾化吸入治疗急性支气管炎能增强临床疗效,提高细菌清除率,提升免疫功能,减轻机体炎性反应.
Efficacy of piperacillin and sulbactam combined with acetylcysteine aerosol inhalation in the treatment of acute bronchitis
Objective To investigate the efficacy of piperacillin and sulbactam intravenous infusion combined with acetylcysteine aerosol inhalation in the treatment of acute bronchitis and the effects on peripheral blood immunoglobulin,platelet/lymphocyte ratio(PLR)and serum amyloid protein(SAA).Methods A total of 202 children with acute bronchitis treated in the Department of Pediatrics,at the Fourth Affiliated Hospital of Nanjing Medical University from February 2021 to February 2024 were selected.They were divided into two groups:a control group(n=101)receiving acetyl cysteine atomized inhalation treatment,and a treatment group(n=101)receiving intravenous administration of Piperacillin and sulbactam in combination with acetyl cysteine inhalation.The efficacy,bacterial clearance,immunoglobulin,PLR and SAA levels were compared between the two groups.Results The total effective rate of the treatment group was 92.08%,which was higher than that of the control group(78.22%),and the difference was statistically significant(P<0.05).The bacterial clearance rate of the treatment group was 94.06%,which was higher than that of the control group(81.19%),and the difference was statistically significant(P<0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)in both groups were increased,and the increases in the treatment group were greater than those in the acetylcysteine group,with statistical significance(P<0.05).After treatment,the levels of PLR and SAA in both groups decreased,and the decrease rate in the treatment group was greater than that in the control group,with statistical significance(P<0.05).Conclusion Piperacillin and sulbactam combined with acetylcysteine atomized inhalation in the treatment of acute bronchitis can enhance clinical efficacy,increase bacterial clearance,improve immune function,and reduce inflammatory response.

Piperacillin and sulbactamAcetylcysteineAtomizing inhalationAcute bronchitis

殷海珍、高艳如、郭阿林

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南京医科大学第四附属医院儿科,江苏,南京 210031

哌拉西林钠舒巴坦 乙酰半胱氨酸 雾化吸入 急性支气管炎

南京市卫生科技发展专项资金项目

YKK21250

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(10)