Efficacy of piperacillin and sulbactam combined with acetylcysteine aerosol inhalation in the treatment of acute bronchitis
Objective To investigate the efficacy of piperacillin and sulbactam intravenous infusion combined with acetylcysteine aerosol inhalation in the treatment of acute bronchitis and the effects on peripheral blood immunoglobulin,platelet/lymphocyte ratio(PLR)and serum amyloid protein(SAA).Methods A total of 202 children with acute bronchitis treated in the Department of Pediatrics,at the Fourth Affiliated Hospital of Nanjing Medical University from February 2021 to February 2024 were selected.They were divided into two groups:a control group(n=101)receiving acetyl cysteine atomized inhalation treatment,and a treatment group(n=101)receiving intravenous administration of Piperacillin and sulbactam in combination with acetyl cysteine inhalation.The efficacy,bacterial clearance,immunoglobulin,PLR and SAA levels were compared between the two groups.Results The total effective rate of the treatment group was 92.08%,which was higher than that of the control group(78.22%),and the difference was statistically significant(P<0.05).The bacterial clearance rate of the treatment group was 94.06%,which was higher than that of the control group(81.19%),and the difference was statistically significant(P<0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)in both groups were increased,and the increases in the treatment group were greater than those in the acetylcysteine group,with statistical significance(P<0.05).After treatment,the levels of PLR and SAA in both groups decreased,and the decrease rate in the treatment group was greater than that in the control group,with statistical significance(P<0.05).Conclusion Piperacillin and sulbactam combined with acetylcysteine atomized inhalation in the treatment of acute bronchitis can enhance clinical efficacy,increase bacterial clearance,improve immune function,and reduce inflammatory response.
Piperacillin and sulbactamAcetylcysteineAtomizing inhalationAcute bronchitis