Efficacy of piperacillin/tazobactam sodium combined with tiotropium bromide powder in?halation in the treatment of bronchiectasis and its effect on T cell subsets and inflamma?tory factors
Objective To investigate the efficacy of piperacillin/tazobactam sodium(PIP/TAZO)combined with tiotropium bromide(TIO)powder inhalation in the treatment of bronchiectasis and its effect on T cell subsets and inflammatory factors.Methods A total of 100 patients with bronchiectasis who received treatment in Zigong First People's Hospital from August 2022 to January 2024 were randomly divided into TIO group(n=50,using TIO powder inhalation)and combination group(n=50,using PIP/TAZO on the basis of the conventional group)by the random number table method.The clinical efficacy,pulmonary function in⁃dexes,bronchiectasis severity index(BSI),inflammatory factors level and T cell subsets proportion were compared between the two groups.Results After one month of treatment,the pulmonary function indexes,including forced expiratory volume in one second(FEV1)and FEV1/forced vital capacity(FVC),were nota⁃bly higher than the TIO group,while the BSI score was significantly lower than the TIO group,with these dif⁃ferences being statistically significant(P<0.05).The effective rate of the combined group was higher than the TIO group,and the difference was statistically significant(P<0.05).Following treatment,the combined group displayed notably reduced levels of C⁃reactive protein(CRP),procalcitonin(PCT)and neutrophil⁃to⁃lympho⁃cyte ratio(NLR)compared to the TIO group,and all the differences were statistically significant(P<0.05).The proportions of CD4+and CD4+/CD8+in the combined group were significantly higher than those in the TIO group,and the proportion of CD8+in the combined group was significantly lower than that in the TIO group,all of which were statistically significant(P<0.05).Conclusion The combination of piperacillin/tazobactam sodium and TIO powder inhalation in the treatment of bronchiectasis has good clinical efficacy,which can ef⁃fectively reduce the degree of bronchiectasis,improve the respiratory function of the lungs,and reduce the in⁃flammatory response of the respiratory system.
万方数据
维普
