The effect of dexmedetomidine on serum CK?MB,cTnI,and NT?proBNP in patients with CHD undergoing non?cardiac surgery
Objective To investigate the effects of dexmedetomidine on serum creatine kinase iso⁃enzyme MB(CK⁃MB),cardiac troponin I(cTnI),and N⁃terminal B⁃type brain natriuretic peptide precursor(NT proBNP)in non⁃cardiac surgical patients with coronary heart disease(CHD).Methods There was no statistically significant difference between the two groups in terms of infusion volume,bleeding volume,extu⁃bation time,recovery time,surgical time,and hospital stay(P>0.05).70 CHD non⁃cardiac surgery patients were admitted to Linquan County People's Hospital from January 2021 to December 2022.They were divided into the control group(35 cases)and the experimental group(35 cases),all of whom received conventional general anesthesia.In the experimental group,Dexmedetomidine hydrochloride injection was given intrave⁃nously 10 minutes before anesthesia induction.In the control group,0.9％sodium chloride injection was given intravenously.All patients were observed for 2 days after surgery.The surgical conditions,vital signs,levels of stress index,myocardial injury index and cardiovascular adverse events were compared between the two groups.Results Compared to 15 minutes before anesthesia induction,the diastolic blood pressure(DBP),heart rate(HR),and systolic blood pressure(SBP)of both groups showed an increasing trend after anesthesia induction,immediately after intubation,and 1 minute after intubation.The experimental group had lower values than the control group,and these differences were statistically significant(P<0.05).Compared to 15 minutes be⁃fore anesthesia induction,the levels of serum interleukin⁃6(IL⁃6),tumor necrosis factor⁃α(TNF⁃α),cortisol(Cor),norepinephrine(NE),CK⁃MB,cTnI,and NT⁃proBNP increased at the end of surgery in both groups.However,the experimental group had lower levels than the control group,and these differences were statisti⁃cally significant(P<0.05).Compared to the end of surgery,the levels of serum IL⁃6,TNF⁃α,Cor,NE,CK⁃MB,cTnI,and NT⁃proBNP decreased in both groups,with the experimental group having lower levels than the control group,and these differences were statistically significant(P<0.05).The total incidence of cardiovascular adverse events during the perioperative period in the experimental group was lower than in the control group,and these differences were statistically significant(P<0.05).Conclusion Dexmedetomidine can improve the vital signs of non⁃cardiac surgery patients with CHD,regulate serum CK⁃MB,cTnI,and NT proBNP levels,allevi⁃ate myocardial injury,improve stress response,and prevent the occurrence of cardiovascular adverse events.
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