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2018?2021年西北妇女儿童医院住院儿童疾病特征分析

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目的 调查2018-2021 西北妇女儿童医院住院儿童的疾病现状,探讨儿童塑型性支气管炎(PB)的疾病特征.方法 前瞻性纳入西北妇女儿童医院于2018年6月至2021年12月收治的1 226例住院儿童作为研究对象,所有患儿均完善电子支气管镜检查,并根据其检查结果将患儿分为PB组(n=252)和非PB组(n=974),比较两组患者的一般资料、临床表现、病原学检测结果差异.结果 1 226例住院儿童中共诊断出252例PB儿童,PB发生率为20.55%,PB组平均年龄、低质量患儿比例、1~3月发病率均明显高于非PB组,差异有统计学意义(P均<0.05).PB组出现发热、气喘、呼吸急促及胸腔积液的患儿比例明显偏高非PB组,差异有统计学意义(P均<0.05),且PB组热峰、热程及病程显著高于非PB组,差异有统计学意义(P均<0.05).PB组患者在院期间均接受抗生素治疗,其中181例采用地塞米松或甲泼尼龙治疗,123例接受人免疫球蛋白静脉注射治疗,52例接受吸氧治疗,38无创机械辅助通气治疗,45例行机械通气治疗.79.37%的患儿接受支气管检查次数≥2次.结论 通过支气管镜检查及肺泡灌洗液病原体检测,有助于准确诊断PB并制定治疗方案.及时的抗生素治疗和必要时的机械通气对于改善PB患儿预后具有重要意义.
Analysis of disease characteristics of children hospitalized in northwest women and children's hospital from 2018 to 2021
Objective To investigate the current disease status of hospitalized children at North⁃west Women's and Children's Hospital from 2018 to 2021 and explore the disease characteristics of pediatric plastic bronchitis(PB).Methods All the children underwent electronic bronchoscopy.According to the ex⁃amination results,they were divided into two groups:PB group(n=252)and non⁃PB group(n=974).The differences in general information,clinical manifestations and pathogen detection results between the two groups were compared.Results In this study,a total of 252 children with PB were diagnosed out of 1,226 hospitalized children,resulting in an incidence rate of 20.55%.The mean age,proportion of low⁃quality chil⁃dren,and incidence rate from 1 to 3 months in the PB group were significantly higher than those in the non⁃PB group(P<0.05).Children in the PB group presented with symptoms such as fever,shortness of breath,short⁃ness of breath,and pleural effusion at a significantly higher in the non⁃PB group(P<0.05).Additionally,the peak fever,duration of fever,and illness duration were all significantly higher in the PB group compared to the non⁃PB group,with statistically significant differences(P<0.05).All patients in the PB group received an⁃tibiotic treatment during their hospital stay.Specifically,181 patients were treated with dexamethasone or methylprednisolone,123 received human immunoglobulin intravenously,52 received oxygen therapy,38 re⁃ceived non⁃invasive mechanically assisted ventilation,and 45 were placed on routine mechanical ventilation.Furthermore,79.37%of children in the PB group underwent bronchoscopy≥2 times.Conclusion Bronchos⁃copy and detection of pathogens in alveolar lavage fluid are helpful in accurately diagnosing PB and developing treatment plans.Timely antibiotic treatment and,when necessary,mechanical ventilation are of great signifi⁃cance in improving the prognosis of children with PB.

ChildrenPlastic bronchitisDisease characteristics

魏曦、余慧、李晓菲、卫翠

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西北妇女儿童医院儿科重症科,陕西,西安 710061

西北妇女儿童医院儿童呼吸科,陕西,西安 710061

兵器工业五二一医院新生儿科,陕西,西安 710065

儿童 塑型性支气管炎 疾病特征

陕西省重点研发计划

2022SF?278

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(10)