Effects of serum relaxin H2,E2,and 25(OH)D levels on pelvic floor function and vaginal exfoliated cell maturity in perimenopausal women
Objective To analyze the effects of serum relaxin(H2),estrogen(E2)and 25⁃hy⁃droxy vitamin D[25(OH)D]levels on pelvic floor function and vaginal exfoliated cell maturity in perimeno⁃pausal women.Methods A total of 79 perimenopausal women with pelvic floor dysfunction(PFD)who were treated in our hospital from May 2022 to June 2024 were selected as the observation group,and 80 healthy peri⁃menopausal women(without pelvic diseases)who underwent physical examinations in our hospital during the same period were selected as the control group.The levels of H2,E2,25(OH)D,pelvic floor function and vaginal exfoliated cell maturity were compared between the two groups.The Pearson correlation coefficient was used to analyze the correlation between H2,E2,25(OH)D levels and pelvic floor function as well as vaginal exfoliated cell maturity in perimenopausal patients.Results The levels of H2 in the observation group were higher than those in the control group,and the levels of E2 and 25(OH)D were lower than those in the control group,the differences were statistically significant(P<0.05).The resting electromyography value of the obser⁃vation group was greater than that of the control group,and the maximum contraction force and continuous con⁃traction force were smaller than those in the control group,the differences were statistically significant(P<0.05).The maturity of vaginal exfoliated cells in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).According to Pearson correlation analysis,H2 was nega⁃tively correlated with resting myoelectric value,maximum contractility,sustained contractility and maturity of vaginal exfoliated cells.Binary logistic multivariate analysis showed that H2,E2 and 25(OH)D levels were in⁃dependent risk factors affecting pelvic floor function and maturity of vaginal exfoliated cells in perimenopausal patients(P<0.05).E2 and 25(OH)D were positively correlated with resting myoelectric value,maximum con⁃tractility,sustained contractility and maturity of vaginal exfoliated cells(P<0.05).Conclusion The level of serum H2 increased in perimenopausal PDF patients,while the levels of E2 and 25(OH)D decreased.All three factors were found to be associated with pelvic floor function and the maturity of vaginal exfoliated cells.
H2E225(OH)DPerimenopauseMaturity of vaginal exfoliated cells
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