首页|2型糖尿病合并乙型肝炎肝硬化相关肝细胞癌患者血清TNF?a、HSP70、sPD?1的水平及意义

2型糖尿病合并乙型肝炎肝硬化相关肝细胞癌患者血清TNF?a、HSP70、sPD?1的水平及意义

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目的 探讨 2 型糖尿病合并乙型肝炎肝硬化相关肝细胞癌患者血清肿瘤坏死因子⁃a(TNF⁃a)、热休克蛋白70(HSP70)、可溶性程序性细胞死亡蛋白1(sPD⁃1)的水平及意义.方法 采用前瞻性研究方法,选取2022年1月至2023年6月98例2型糖尿病合并乙型肝炎肝硬化患者作为观察组,同时选取81例单纯性乙型肝炎肝硬化患者、单纯2型糖尿病患者60例、健康志愿者60名作为对照.根据是否合并肝细胞癌将观察组分为肝细胞癌组31例、非肝细胞癌67例组.检测所有研究对象血清TNF⁃a、HSP70和sPD⁃1水平.结果 观察组血清TNF⁃a、HSP70明显高于乙肝肝硬化组、2型糖尿病组和健康志愿者,差异有统计学意义(P<0.05);观察组SPD⁃1明显低于乙肝肝硬化组、2型糖尿病组和健康志愿者,差异有统计学意义(P<0.05).肝细胞癌组患者血清TNF⁃a、HSP70 明显高于非肝细胞癌组,差异有统计学意义(P<0.05);肝细胞癌组患者血清SPD⁃1明显低于非肝细胞癌组,差异有统计学意义(P<0.05).血清TNF⁃a、HSP70和sPD⁃1诊断2型糖尿病合并乙型肝炎肝硬化肝细胞癌的ROC曲线下面积(AUC)分别为0.812、0.749、0.848(P<0.01).结论 2型糖尿病合并乙型肝炎肝硬化相关肝细胞癌患者血清TNF⁃a、HSP70、sPD⁃1水平明显升高,在疾病诊治中可能有一定应用价值.
Serum levels of TNF?a,HSP70 and sPD?1 in hepatocellular carcinoma with hepatitis B cirrhosis and type 2 diabetes mellitus and their significance
Objective To investigate the serum levels of tumor necrosis factor⁃a(TNF⁃a),heat shock protein 70(HSP70)and soluble programmed cell death protein 1(sPD⁃1)in hepatocellular carcinoma(HCC)patients with hepatitis B cirrhosis and type 2 diabetes mellitus.Methods Prospective research methods were used,98 patients with type 2 diabetes mellitus and hepatitis B cirrhosis who were treated from January 2022 to June 2023 were selected as the observation group,and 81 patients with hepatitis B cirrhosis,60 patients with type 2 diabetes mellitus and 60 healthy volunteers were selected as controls.In addition,the observation group was divided into two subgroups:the hepatocellular carcinoma group with 31 cases and the non⁃hepatocellular car⁃cinoma group,which had 67 cases.The serum levels of TNF⁃a,HSP70,and sPD⁃1 were then detected.Results The serum levels of TNF⁃a and HSP70 in the observation group were significantly higher than those in the hepati⁃tis B cirrhosis group,the type 2 diabetes group and the healthy volunteers,the difference was statistically signifi⁃cant(P<0.05).The levels of sPD⁃1 in the observation group were significantly lower than those in the hepatitis B cirrhosis group,the type 2 diabetes group and the healthy volunteers,the difference was statistically significant(P<0.05).The serum levels of TNF⁃a and HSP70 in hepatocellular carcinoma group were significantly higher than those in the non⁃hepatocellular carcinoma group.The difference was statistically significant(P<0.05).The sPD⁃1 in the observation group was significantly lower than those in the non⁃hepatocellular carcinoma group.The difference was statistically significant(P<0.05).The area under the ROC curve(AUC)of serum TNF⁃a,HSP70,and sPD⁃1 in the diagnosis of type 2 diabetes mellitus complicated with hepatitis B cirrhosis and hepato⁃cellular carcinoma were 0.812,0.749 and 0.848 respectively(P<0.01).Conclusion The serum levels of TNF⁃a,HSP70,and sPD⁃1 in hepatocellular carcinoma patients with hepatitis B cirrhosis and type 2 diabetes mellitus are significantly increased.This may have some application value in disease diagnosis and treatment.

Type 2 diabetes mellitusHepatitis B cirrhosisHepatocellular carcinomaTumor ne-crosisafactor-aHeat shock protein 70Soluble programmed cell death protein 1

李矫捷、孙丽、张红红

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淄博一四八医院感染科,山东,淄博 255300

临清市人民医院感染科护理,山东,聊城 252600

青岛滨海学院附属医院病理科,山东,青岛 266500

2型糖尿病 乙型肝炎肝硬化 肝细胞癌 肿瘤坏死因子⁃a 热休克蛋白70 可溶性程序性细胞死亡蛋白1

淄博市科学技术发展计划项目

2021kj062239

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(10)