Serum levels of TNF?a,HSP70 and sPD?1 in hepatocellular carcinoma with hepatitis B cirrhosis and type 2 diabetes mellitus and their significance
Objective To investigate the serum levels of tumor necrosis factor⁃a(TNF⁃a),heat shock protein 70(HSP70)and soluble programmed cell death protein 1(sPD⁃1)in hepatocellular carcinoma(HCC)patients with hepatitis B cirrhosis and type 2 diabetes mellitus.Methods Prospective research methods were used,98 patients with type 2 diabetes mellitus and hepatitis B cirrhosis who were treated from January 2022 to June 2023 were selected as the observation group,and 81 patients with hepatitis B cirrhosis,60 patients with type 2 diabetes mellitus and 60 healthy volunteers were selected as controls.In addition,the observation group was divided into two subgroups:the hepatocellular carcinoma group with 31 cases and the non⁃hepatocellular car⁃cinoma group,which had 67 cases.The serum levels of TNF⁃a,HSP70,and sPD⁃1 were then detected.Results The serum levels of TNF⁃a and HSP70 in the observation group were significantly higher than those in the hepati⁃tis B cirrhosis group,the type 2 diabetes group and the healthy volunteers,the difference was statistically signifi⁃cant(P<0.05).The levels of sPD⁃1 in the observation group were significantly lower than those in the hepatitis B cirrhosis group,the type 2 diabetes group and the healthy volunteers,the difference was statistically significant(P<0.05).The serum levels of TNF⁃a and HSP70 in hepatocellular carcinoma group were significantly higher than those in the non⁃hepatocellular carcinoma group.The difference was statistically significant(P<0.05).The sPD⁃1 in the observation group was significantly lower than those in the non⁃hepatocellular carcinoma group.The difference was statistically significant(P<0.05).The area under the ROC curve(AUC)of serum TNF⁃a,HSP70,and sPD⁃1 in the diagnosis of type 2 diabetes mellitus complicated with hepatitis B cirrhosis and hepato⁃cellular carcinoma were 0.812,0.749 and 0.848 respectively(P<0.01).Conclusion The serum levels of TNF⁃a,HSP70,and sPD⁃1 in hepatocellular carcinoma patients with hepatitis B cirrhosis and type 2 diabetes mellitus are significantly increased.This may have some application value in disease diagnosis and treatment.
Type 2 diabetes mellitusHepatitis B cirrhosisHepatocellular carcinomaTumor ne-crosisafactor-aHeat shock protein 70Soluble programmed cell death protein 1