The application value of serum AGEs,IL?6 and PCT in predicting premature delivery and premature rupture of membranes in pregnant women
Objective To explore the application value of serum advanced glycation end products(AGEs),interleukin⁃6(IL⁃6)and procalcitonin(PCT)in predicting premature delivery and premature rupture of membranes in pregnant women.Methods In this study,a retrospective method was used to select 120 preg⁃nant women with premature rupture of membranes admitted to Xingtai Central Hospital from January 2020 to December 2023 as the experimental group,and 118 pregnant women with normal pregnancy test results during the same period were selected as the control group.The clinical data including age,education level,parity,abortion history,infection,gestational hypertension,gestational diabetes history,and infection,as well as se⁃rum levels of AGEs,IL⁃6 and PCT were compared between the two groups.A binary logistic regression model was used to analyze the risk factors of premature delivery and premature rupture of membranes in pregnant women.The predictive effects of single and parallel detection of AGEs,IL⁃6,and PCT on premature delivery and premature rupture of membranes in pregnant women were analyzed.Results There was no significant dif⁃ference in age,education level and parity between the two groups(P>0.05).However,significant differences were found in abortion history,infection,gestational hypertension,gestational diabetes history,and infection between the two groups(P<0.05).The levels of serum AGEs,IL⁃6,and PCT in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of AGEs(>30 μg/mL),IL⁃6(>0.463 ng/L),and PCT(>0.5 ng/mL)were independent risk factors affecting pre⁃mature delivery and premature rupture of membranes in pregnant women(P<0.05).The ROC curve showed that the AUC of AGEs,IL⁃6,and PCT in parallel detection of premature delivery and premature rupture of mem⁃branes in pregnant women was 0.906,which was significantly higher than that of AGEs,IL⁃6,and PCT alone(P<0.05).Conclusion The levels of serum AGEs,IL⁃6,and PCT have a significant value in predicting pre⁃mature delivery and premature rupture of membranes in pregnant women.The parallel detection accuracy of the three markers is the highest,providing valuable references for clinical treatment and diagnosis.
AGEsIL-6PCTPreterm labourPremature rupture of membranes
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