Prognostic value of serum NGAL,urinary β2?MG and UACR in early nephropathy with type 2 diabetes mellitus
Objective To investigate the predictive value of serum neutrophil gelatinase⁃associated lipid carrier protein(NGAL),β2⁃microglobulin(β2⁃MG)and urinary albumin to creatinine ratio(UACR)in early nephropathy of type 2 diabetes mellitus.Methods A total of 106 patients with type 2 diabetic early ne⁃phropathy admitted to the Fifth Medical Center of the PLA General Hospital and Hanzhong Central Hospital from August 2021 to July 2023 were selected as the study group,and 56 patients with diabetes only were se⁃lected as the control group.Clinical data of all subjects were collected,and the general data and serum NGAL,urinary β2⁃MG and UACR levels were compared between the two groups.Multivariate logistic regression was used to analyze the influencing factors of early nephropathy in type 2 diabetes mellitus.Pearson correlation was used to analyze the correlation between serum NGAL,urinary β2⁃MG,UACR and renal function,and receiver operating characteristic curve(ROC)and area under the curve(AUC)were used to evaluate the predictive value of serum NGAL,urinary β2⁃MG,UACR in early nephropathy of type 2 diabetes.Results The levels of eGFR,CysC,BUN,NGAL,β2⁃MG,and UACR were compared between the two groups,and the differences were statistically significant(P<0.05).The results of multivariate logistic regression analysis showed that eGFR,CysC,BUN,NGAL,β2⁃MG,and UACR levels were all factors affecting the occurrence of early ne⁃phropathy in type 2 diabetes mellitus(P<0.05).The results of Pearson correlation analysis showed that serum NGAL,urinary β2⁃MG,and UACR were negatively correlated with eGFR(P<0.05).The ROC curve showed that the AUC area of serum NGAL,urinary β2⁃MG,UACR,and their combination in predicting early ne⁃phropathy of typeⅡdiabetes was 0.879,0.887,0.890 and 0.990,respectively,indicating that the three had good predictive value,and the combined prediction effect of the three was the best(P<0.05).Conclusion Se⁃rum NGAL,urinary β2⁃MG and UACR are all influential factors for the occurrence of early nephropathy in type 2 diabetes mellitus.These three factors have certain predictive value for the occurrence of early nephropathy in type 2 diabetes mellitus,and their combined predictive effect is the strongest.
万方数据
