Serotype distribution and drug resistance analysis of clinical isolates of Streptococcus pneu-moniae in a hospital in Tai'an City
Objective To investigate the clinical characteristics,serotypes and drug resistance of Streptococcus pneumoniae(S.pneumoniae),and to provide the basis for clinical treatment.Methods S.pneu-moniae was isolated from various specimens at the Affiliated Taian City Central Hospital of Qingdao University from January to December of 2019.Drug sensitivity tests were determined using the disk diffusion method and concentration gradient method(E⁃test),serological tests were carried out by capsule swelling test.The coverage of vaccine to serotype was analyzed statistically.Results A total of 104 S.pneumoniae samples were collected with sputum being the most common specimen,accounting for 83.65％(87/104).65.38％(68/104)of the pa⁃tients were under 6 years old.The sensitivity rate of penicillin was 100.00％,while the sensitivity rates of levo⁃floxacin and chloramphenicol were high(>92.00％).However,the resistance rates of erythromycin,clindamy⁃cin and tetracycline were also high(>92.00％).No resistant strains were found for ceftriaxone,meropenem,li⁃nezolid,vancomycin and moxifloxacin.They were divided into 18 serotypes.The common serotypes were 19F,19A,6B,and 6A.The coverage of the S.pneumoniae vaccine was 82.69％for PCV13 and 89.42％for PPV23.There was no significant difference in the resistance rate to antibiotics among the four common serotypes.Con⁃clusion The most common S.pneumoniae infections occur in infants and young children.The major serotypes are 19F,19A,6B,and 6A.The coverage of PCV13 and PPV23 vaccines is high and deserving of promotion.
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