Analysis of risk factors for the development of neonatal infections and correlation of serum PCT,IL?6 and CRP with neonatal infections
Objective To study and analyze the risk factors that affect the occurrence of neonatal in⁃fection,and further analyze the changes in serum levels of procalcitonin(PCT),interleukin⁃6(IL⁃6),and C⁃re⁃active protein(CRP)in neonatal infection,and diagnostic value in the occurrence of neonatal infection.Meth⁃ods A total of 351 newborns were admitted to Guangzhou Women's and Children's Medical Center Liuzhou Hospital from March 2021 to March 2024.They were divided into an infected group(n=116)and a non⁃infected group(n=235)based on whether an infection occurred.Serum levels of PCT,IL⁃6,and CRP were measured.Bi⁃nary logistic regression was applied to analyze the influencing factors of neonatal infection.Receiver operating characteristic(ROC)curves were plotted to assess the diagnostic value of serum PCT,IL⁃6,and CRP for neona⁃tal infection.Results Among 116 newborns with infections,the infection sites included the respiratory system(33.62％),blood system(6.90％),digestive system(21.55％),urinary system(12.93％),skin tissue(17.24％),and others(7.76％).After pathogen isolation and identification,the results showed that the infected pathogens in the children were Gram negative bacteria(62.06％),Gram positive bacteria(35.35％),and fungi(2.59％).There were statistical differences between the two groups in terms of gestational age,amniotic fluid contamination,duration of antibiotic use,length of hospital stays,admission to NICU,Apgar score,and birth weight(P<0.05).The serum levels of PCT,IL⁃6,and CRP in the infected group were obviously higher than those in the non⁃infected group,the difference is statistically significant(P<0.05).Gestational age,duration of antibi⁃otic use,length of hospital stay,Apgar score,birth weight,and elevated levels of PCT,IL⁃6,and CRP were all risk factors for neonatal infection(P<0.05).The AUC of serum PCT,IL⁃6,and CRP combined for diagnosing neonatal infections was 0.890,significantly better than diagnosis alone(P<0.05).Conclusion Serum PCT,IL⁃6,and CRP levels are elevated in neonatally infected children and are associated with gestational age,duration of antimicrobial use,length of hospitalization,Apgar score,and birth weight as risk factors for neonatal infection.
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