Prognostic value of TG/Cys?C,adiponectin and VILIP?1 levels in peripheral blood in patients with type 2 diabetes complicated with acute ischemic stroke
Objective To explore the prognostic value of triglyceride(TG)/cystatin(Cys⁃C),adi⁃ponectin,and tryponoid protein 1(VILIP⁃1)levels in peripheral blood in patients with type 2 diabetes mellitus(T2DM)complicated with acute ischemic stroke(AIS).Methods A total of 136 patients with T2DM com⁃bined with AIS were admitted to Yuncheng Central Hospital from July 2020 to July 2023 and were retrospec⁃tively selected as the study subjects.Based on the modified Rankin Scale(mRS)score of the patients at a 3⁃month follow⁃up,those with≤2 points were divided into a good group(n=84),and those with>2 points were divided into an adverse group(n=52).The general data and peripheral blood TG/Cys⁃C,adiponectin and VILIP⁃1 levels of the two groups were compared,and the prognostic factors affecting T2DM patients with AIS were ana⁃lyzed by multivariate logistic regression.The predictive value of TG/Cys⁃C,adiponectin and VILIP⁃1 in T2DM patients with AIS was evaluated by the receiver operating characteristic curve(ROC)curve.Results Age,NIHSS score,TG/Cys⁃c,adiponectin and VILIP⁃1 levels were compared between the two groups,and the dif⁃ferences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that age,NIHSS score,TG/Cys⁃C,adiponectin and VILIP⁃1 levels were independent factors affecting the prognosis of T2DM patients with AIS(P<0.05).The ROC curve results showed that the AUC area of peripheral blood TG/Cys⁃c,adiponectin,VILIP⁃1 and their combination in predicting prognosis of T2DM patients with AIS were 0.710,0.725,0.679 and 0.804,respectively.The results indicated that TG/Cys⁃C,adiponectin and VILIP⁃1 lev⁃els in peripheral blood all had certain predictive value for the prognosis of T2DM patients with AIS,and the combined effect of the three was the best,with a sensitivity of 90.5％and a specificity of 75.0％(P<0.05).Con⁃clusion The poor prognosis of T2DM patients with AIS is related to age,NIHSS score,TG/Cys⁃C,adiponec⁃tin,VILIP⁃1 levels,and peripheral blood TG/Cys⁃C,adiponectin,VILIP⁃1 levels have certain predictive value for the prognosis of T2DM patients with AIS.And the combined prediction effect of the three is the highest.
Ratio of triglyceride to cystatin in peripheral bloodAdiponectinTrypanoid protein 1Type 2 diabetesAcute ischemic stroke
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