Expression of UBE2S and FASN proteins in gastric cancer and their clinicopathological significance
Objective To investigate the expression of ubiquitin ⁃ conjugating enzyme E2S(UBE2S)and fatty acid synthetase(FASN)in gastric cancer tissues and their correlation with clinicopatho⁃logical features,survival prognosis.Methods A retrospective analysis was performed on 108 patients with gastric cancer who underwent surgical resection in the Central Hospital of Tujia and Miao Autonomous Prefec⁃ture of Enshi from January 2020 to December 2022.Western blotting was used to assess the protein expression levels of UBE2S and FASN in both gastric cancer tissues and adjacent tissues.The difference of UBE2S and FASN protein expression levels in gastric cancer tissues of patients with different clinicopathological character⁃istics and survival prognosis was compared,and the value of UBE2S and FASN protein expression levels in gastric cancer tissues for survival prognosis was analyzed by ROC curve.Results The protein expression lev⁃els of UBE2S and FASN in gastric cancer tissues were higher than those in adjacent tissues,and the differ⁃ences were statistically significant(P<0.05).The protein expression levels of UBE2S and FASN in TNM stageⅢ gastric cancer tissues were higher than those in TNM stageⅠ to Ⅱ,and the differences were statisti⁃cally significant(P<0.05).Furthermore,the protein expression levels of UBE2S and FASN in gastric cancer tissues with vascular embolus were higher than those without vascular embolus,also showing statistically sig⁃nificant differences(P<0.05).The protein expression levels of UBE2S and FASN in gastric cancer tissues of deceased patients were higher than those of surviving patients,and the differences were statistically significant(P<0.05).The area under the curve of UBE2S and FASN protein expression levels in gastric cancer tissues for evaluating postoperative death were 0.828 and 0.835,respectively,both showing statistical significance(P<0.05).Conclusion The expressions of UBE2S and FASN in gastric cancer increase and are correlated with TNM stage,vascular thrombus and survival prognosis.
万方数据
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