Clinical characterization of Chlamydia psittaci pneumonia
Objective To analyze the clinical characteristics and early diagnosis and treatment of patients with Chlamydia psittaci pneumonia with the aim of increasing awareness of the disease.Methods We collected seven cases of Chlamydia psittaci pneumonia diagnosed by metagenomic next⁃generation sequencing(mNGS)at Qingyuan People's Hospital from December 2020 to March 2023.We retrospectively analyzed the clinical data.including clinical manifestations,laboratory tests,imaging,pathological features,mNGS results,and treatment methods of the patients.Results All 7 cases were male,aged 30 to 79 years old,presenting high fever,headache,and malaise as the main symptoms of the disease.All 7 patients had a decreased lymphocyte ratio and increased C⁃reactive protein levels.6 cases had elevated levels of procalcitonin,alanine aminotransfer⁃ase,aspartate aminotransferase,lactate dehydrogenase,and direct bilirubin,as well as abnormal coagulation function.Additionally,all 7 cases had patchy hyperdense shadows,partly solid,along with bronchial conges⁃tion.4 cases had pleural effusion,and 2 cases had pleural thickening.Five patients underwent transbroncho⁃scopic brushings for cytologic testing,and the pathologic manifestations of the pathology were nonspecific,all of which were inflammatory cell infiltration.All patients were tested using mNGS,and the nucleic acid se⁃quence of Chlamydia psittaci was detected.After the diagnosis was confirmed,doxycycline was selected in com⁃bination with other anti⁃infective drugs,and the patients were discharged from the hospital.Conclusion Chla-mydia psittaci pneumonia has a low incidence and diagnostic difficulties.mNGS is an important test for early di⁃agnosis,which can help to initiate timely and targeted anti⁃infective therapy and improve prognosis.
万方数据
维普
