Effect of Bazhen decoction combined with EPO on tumor chemotherapy related anemia in breast cancer patients and its influence on serum inflammatory factors
Objective To study the therapeutic effect of Bazhen Decoction combined with erythro⁃poietin(EPO)on tumor chemotherapy related anemia in patients with breast cancer and observe the effect on the level of inflammatory factors.Methods 82 patients with chemotherapy related anemia of breast cancer were admitted to Qidong People's Hospital from January 2023 to January 2024 were selected.They were divided into an observation group(n=42,treated with Bazhen Decoction combined with EPO intervention)and a con⁃trol group(n=40,treated with EPO intervention),based on different treatment plans.The treatment effects and incidence of adverse reactions in two groups were recorded,The levels of immune function[CD3+,CD4+,CD8+,and CD4+/CD8+]and inflammatory factors[C⁃reactive protein(CRP)and interleukin⁃6(IL⁃6)]between the two groups before and after intervention were compared.Results After treatment,the levels of serum albu⁃min(Alb),serum prealbumin(PA),and hemoglobin(Hb)in both groups were higher than before treatment,and the observation group had higher levels of Alb,PA,and Hb than those of control group,the difference were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the CD3+,CD4+,and CD4+/CD8+levels in the observation group were significantly higher than those in the control group,and the CD8+levels were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the serum CRP and IL⁃6 levels in the two groups of patients were lower than before treatment,and the serum CRP and IL⁃6 levels in the observation group were lower than those in the control group,the difference were statistically significant(P<0.05).Conclusion Bazhen Decoction combined with EPO has a significant effect on tumor che⁃motherapy related anemia in breast cancer patients.This combination is helpful in correcting anemia,inhibiting the levels of inflammatory factors,and enhancing the immune function of the body.
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