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妊娠期合并甲状腺功能异常现状及影响因素研究

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目的 探讨妊娠期合并甲状腺功能异常现状,并分析相关影响因素.方法 选取2020年 1 月至 2022 年 12 月期间山西白求恩医院妇产科接受产前检查的 2 307 名孕妇为研究对象,通过甲状腺功能检测调查妊娠期合并甲状腺功能异常情况,并利用Logistic回归模型分析甲状腺功能减退症的影响因素.结果 共检出甲状腺功能异常 449 例,异常检出率为 19.46%.以甲状腺功能减退症(362例)为主,占 80.63%.其中,亚临床甲状腺功能减退(68.60%),甲状腺功能减退(12.03%),亚临床甲状腺功能亢进(16.04%),甲状腺功能亢进(3.34%).多因素Logistic回归分析显示,年龄较大、超重/肥胖、不良妊娠史、食用非碘盐、甲状腺疾病家族史、合并妊娠高血压、妊娠糖尿病以及贫血是妊娠期妇女甲状腺功能减退的独立危险因素(P<0.05).讨论 妊娠期合并甲状腺功能异常以甲状腺功能减退症较多见,影响甲状腺功能减退影响因素众多,临床上应针对超重/肥胖、贫血、食用非碘盐以及具有不良妊娠史和甲状腺疾病家族史、妊娠合并症的高龄孕妇进行重点筛查和干预,以降低甲状腺功能异常风险带来的不良妊娠.
Research on the current status and influencing factors of thyroid dysfunction during pregnancy
Objective To explore the current situation of thyroid dysfunction during pregnancy and analyze the relevant influencing factors.Methods A total of 2307 pregnant women who underwent prenatal ex⁃aminations at the Obstetrics and Gynecology Department of Bethune Hospital in Shanxi Province from January 2020 to December 2022 were selected as the research subjects.Thyroid function testing was used to investigate the incidence of thyroid dysfunction during pregnancy,and a logistic regression model was used to analyze the in⁃fluencing factors of hypothyroidism.Results A total of 449 cases of abnormal thyroid function were detected,with an abnormal detection rate of 19.46%.The primary cause was hypothyroidism(362 cases),accounting for 80.63%.Among them,subclinical hypothyroidism(68.60%),hypothyroidism(12.03%),subclinical hyperthy⁃roidism(16.04%),and hyperthyroidism(3.34%).Multivariate logistic regression analysis showed that older age,overweight/obesity,history of adverse pregnancy,consumption of non⁃iodized salt,family history of thy⁃roid disease,pregnancy hypertension,pregnancy diabetes and anemia were independent risk factors for hypothy⁃roidism in pregnant women(P<0.05).Conclusion Hypothyroidism is a common complication of thyroid dys⁃function during pregnancy,and there are many factors that can affect its development.In clinical practice,it is important to focus on screening and intervention for older pregnant women who are overweight/obese,anemic,consume non⁃iodized salt,have a history of adverse pregnancy,thyroid disease family history,and pregnancy complications.This is done to reduce the risk of adverse pregnancy outcomes caused by thyroid dysfunction.

Pregnancy periodAbnormal thyroid functionHypothyroidismInfluence factor

李红、曹涛、崔献梅、刘瑞利、李洁、任慧花、王娇

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山西白求恩医院(山西医学科学院),山西医科大学第三医院

同济山西医院妇产科,山西,太原 030032

山西医科大学第一医院产科,山西,太原 030001

山西省人民医院产科,山西,太原 030012

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妊娠期 甲状腺功能异常 甲状腺功能减退症 影响因素

山西省基础研究计划任务书

202105072351369

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(10)
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