Effects of vitamin D combined with recombinant human growth hormone on growth and development,serum ghrelin,IGF?1 and IGFBP?3 in children with idiopathic short stature
Objective To explore the curative effect of vitamin D(VD)combined with recombi⁃nant human growth hormone(rhGH)and its influences on growth and development indexes,serum ghrelin(Ghrelin),insulin⁃like growth factor 1(IGF⁃1)and insulin⁃like growth factor binding protein⁃3(IGFBP⁃3)in children with idiopathic short stature.Methods A total of 152 children with idiopathic short stature treated at the First Affiliated Hospital of Henan University of Science and Technology were enrolled between June 2021 and August 2023.Based on random number table method,they were divided into the hGH group and the VD⁃hormone group,with 76 cases in each group.The hGH group was treated with growth hormone(hGH),while the VD⁃hormone group was treated with vitamin D+rhGH for 3 months.The growth and development indexes(height,body mass,bone age,growth rate),bone metabolism indexes[25⁃hydroxyvitamin D[25(OH)D,bone alkaline phosphatase(BAP),osteocalcin(OC)],thyroid function indexes[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)],serological indexes(IGF⁃1,IGFBP⁃3)and the in⁃cidence of adverse reactions in the two groups were compared.Results After treatment,the height,body mass,bone age and growth rate in the VD⁃hormone group were higher than those in the hGH group(P<0.05).The levels of 25(OH)D,BAP and OC in the VD⁃hormone group were higher than those in the hGH group(P<0.05).The FT3 level in the VD⁃hormone group was higher than that in the hGH group,and both FT3 and FT4 lev⁃els increased after treatment(P<0.05).The ghrelin level in the VD⁃hormone group was lower than that in the hGH group,while IGF⁃1and IGFBP⁃3 levels were higher than those in the hGH group(P<0.05).There was no signifi⁃cant difference in the incidence of adverse reactions between the VD⁃hormone group and the hGH group(18.42％vs 11.84％,P>0.05).Conclusion Vitamin D combined with rhGH can effectively promote growth and develop⁃ment,improve bone metabolism,and enhance thyroid function in children with idiopathic short stature.
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