Relationship between serum notch1,caspase?3,ROS levels and the severity and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To investigate the relationship between serum levels of notch1,cysteinyl as⁃partate specific proteinase⁃3(Caspase⁃3)and reactive oxygen species(ROS)and the severity and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 96 patients with AECOPD hospitalized at Sanmenxia Hospital of the Yellow River from January 2022 to January 2024 were selected as the AECOPD group,60 patients with stable COPD admitted to the outpatient department during the same period were selected as the stable COPD group,and 60 healthy volunteers who underwent physical exami⁃nations during the same period were selected as the control group.The condition of AECOPD was evaluated and divided into mild subgroup,moderate subgroup and severe subgroups.The efficacy of AECOPD was evaluated and divided into effective and ineffective subgroups.The levels of serum notch1,caspase⁃3 and ROS were de⁃tected,and the differences in serum indicators among the three groups and among the subgroups were com⁃pared,the predictive effect of serum indicators on the treatment prognosis of AECOPD patients was analyzed.Results The comparison of levels of serum notch1,caspase⁃3 and ROS were AECOPD group>stable COPD group>control group,the difference was statistically significant(F=137.485,207.391,155.692,P<0.05),se⁃vere subgroup>moderate subgroup>mild subgroup,the difference was statistically significant(F=43.595,31.586,53.182,P<0.05),the ineffective subgroup was higher than the effective subgroup,and the difference was statistically significant(t=4.586,2.289,5.937,P<0.05).The area under the curve(AUC)of serum notch1,caspase⁃3 and ROS levels independently and jointly predicted the prognosis of AECOPD patients were 0.754,0.626,0.846,0.976,and the AUC of combined prediction was greater than that of single prediction(Z=5.856,7.322,4.552,P<0.05).Conclusion The levels of serum notch1,caspase⁃3 and ROS in AECOPD pa⁃tients are related to the exacerbation of the disease and can serve as predictors of prognosis.
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