Relationship between LCR and disease and short?term prognosis in cases with acute isch?emic stroke
Objective To investigate the relationship between lymphocyte/C⁃reactive protein ratio(LCR)and disease condition and short⁃term prognosis in cases with acute ischemic stroke(AIS).Methods A total of 102 AIS patients were admitted to our hospital from August 2022 to July 2023 and were selected as the subjects of this study.They were divided into three groups:mild group(n=34),moderate group(n=52)and se⁃vere group(n=16)based on the National Institutes of Health Stroke Scale(NIHSS).Additionally,they were categorized into a good prognosis group(n=77)and a bad prognosis group(n=25)based on their 3⁃month fol⁃low⁃up prognosis.The levels of peripheral blood lymphocytes(LYM),C⁃reactive protein(CRP)and LCR in AIS patients with different conditions and short⁃term prognoses were compared.The predictive value of periph⁃eral blood LYM,CRP,and LCR in AIS patients was evaluated using ROC analysis.Furthermore,factors af⁃fecting the short⁃term prognosis of AIS patients were investigated through binary logistic stepwise regression analysis.Results The levels of LYM and LCR in peripheral blood were as follows:mild group>moderate group>severe group.While the levels of CRP in peripheral blood were as follows:mild group<moderate group<severe group(P<0.05).The levels of peripheral blood LYM and LCR in the poor prognosis group were lower compared with the good prognosis group,and the levels of peripheral blood CRP were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of peripheral blood LYM,CRP,and LCR in predicting the short⁃term prognosis of AIS patients were 0.752,0.869,and 0.902,respectively.The propor⁃tion of individuals aged≥60 years in the poor prognosis group,the proportion of diabetes history,the time from onset to admission,the NIHSS score at admission,and the maximum lesion diameter in the poor prognosis group were higher compared with the good prognosis group(P<0.05).Age≥60 years old,time from onset to admis⁃sion≥6 h,NIHSS score≥20 at admission,and lower LCR level were identified as risk factors for prognosis in AIS cases(P<0.05).Conclusion The decrease in LCR levels in peripheral blood is associated with the aggrava⁃tion of AIS patients and a poor short⁃term prognosis.It also has a certain predictive value for short⁃term prognosis.
Acute ischemic strokeLymphocyte/C-reactive protein ratio
万方数据
维普
