Effects of MEBO on wound healing and PI3K/Akt/eNOS pathway in elderly patients after burn and plastic surgery
Objective To analyze the effects of MEBO on wound healing and PI3K/Akt/eNOS pathway in elderly patients after burn and plastic surgery.Methods 116 elderly patients with burn and plastic surgery treated at Yibin Second People's Hospital from March 2022 to July 2023 were analyzed and divided into the intervention group(n=58)and the control group(n=58)based on random number method.Both groups were treated with normal saline for wound cleaning,while the control group was treated with Vaseline oil gauze based on normal saline debridement.Intervention group was treated with MEBO based on the control group.EGF and bFGF levels were detected by ELISA,and PI3K,Akt and eNOS protein expression levels were de⁃tected by western blot.Clinical efficacy,wound healing(wound healing time,wound healing rate,and granula⁃tion growth area)of the two groups were compared.Pain index(VAS score),protein expression of PI3K/Akt/eNOS pathway(PI3K,Akt,eNOS)in granulation tissue,EGF and bFGF levels were compared between the two groups before and after treatment.Results The clinical efficacy,wound healing rate and granulation growth area of the intervention group were higher than those of the control group,with statistical significance(P<0.05).The wound healing time was less than that of the control group,and the difference was statistically significant(P<0.05).The levels of PI3K,Akt,eNOS protein,EGF and bFGF in granulation tissue of 2 groups were higher than before treatment,and the intervention group was higher than the control group,with statistical significance(P<0.05).The VAS scores for both groups were lower than before treatment,and the intervention group was lower than the control group,with statistical significance(P<0.05).Conclusion MEBO can effec⁃tively relieve pain and improve EGF and bFGF levels in elderly patients after burn and plastic surgery.This may be related to the regulation of the PI3K/Akt/eNOS pathway.
万方数据
维普
