Serum ET?1 and miR?517c expression in placental abruption and its clinical value
Objective To detect the expressions of endothelin⁃1(ET⁃1)and microRNA⁃517c(miR-517c)in the serum of pregnant women with placental abruption,and to explore the clinical value of both.Methods From June 2016 to June 2019,173 pregnant women suspected of having placental abruption after undergoing tests at in Handan Central Hospital were chosen for the observation group.Pathological exami⁃nation showed that 104 cases had placental abruption in the placental abruption group,while 69 cases without placental abruption were placed in the group without placental abruption.Among the placental abruption group,66 cases were classified as mild and 38 cases as severe.Additionally,150 normal pregnant women were selected as the control group.The expression level of miR-517c in serum was measured using qRT⁃PCR,and the expression of ET⁃1 in serum was detected by ELISA.The expression levels of ET⁃1 and miR⁃517c in the serum of pregnant women with placental abruption of different clinical pathological features were analyzed.The ROC curve was used to analyze the diagnostic value of ET⁃1 and miR-517c in placental abruption.Results The levels of ET⁃1 and miR-517c in the serum of pregnant women in the observation group were sig⁃nificantly higher than those in the control group,and the differences were statistically significant(P<0.05).The expression levels of ET⁃1 and miR-517c in the severe early exfoliation group were higher than those in the mild early exfoliation group,and the proportion of postpartum hemorrhage in the severe early exfoliation group was higher than that in the mild early exfoliation group,and the differences were statistically significant(P<0.05).In pregnant women with high expression of ET⁃1 and miR⁃517c,the proportion of severe cases and those without DIC and PPT was significantly higher than that of mild cases and those with DIC and PPT(P<0.05).The area under the ROC curve(AUC)of the expression level of ET⁃1 in serum in the diagnosis of pla⁃cental abruption was 0.643,with a sensitivity of 0.548,and a specificity of 0.768.The AUC of the expression level of miR-517c in serum in the diagnosis of placental abruption was 0.765,with a sensitivity of 0.683,and a specificity of 0.783.The AUC of the combination was 0.783,with a sensitivity of 0.625,and a specificity of 0.870.Conclusion Serum ET⁃1 and miR⁃517c were highly expressed in patients with placental abruption.Both markers have diagnostic value for detecting placental abruption.
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