Value of combined detection of serum sICAM?3,ET?1 and sEndoglin levels in the risk assessment of recurrence after aortic dissection
Objective To analyze soluble intercellular adhesion molecule⁃3(sICAM⁃3),endothe⁃lin⁃1(ET⁃1)and endothelin(Soluble Endoglin,soluble endoglin,soluble endoglin,soluble intercellular adhe⁃sion molecule⁃3(SICAM⁃3)in serum and to evaluate the value of combined tests of sEndoglin(sEng)levels in the risk assessment of recurrence after aortic dissection.Methods A total of 102 patients who underwent Stan⁃ford Type B aortic dissection at the Second Hospital of Hebei Medical University from March 2018 to May 2023 were retrospectively included.These patients were divided into a recurrence group(16 cases)and a non⁃recur⁃rence group(86 cases).The general data,sICAM⁃3,ET⁃1 and sEng levels were compared between the two groups.The risk factors for postoperative recurrence of aortic dissection were analyzed,and an ROC curve was drawn to evaluate the predictive value of sICAM⁃3,ET⁃1,and sEng alone and in combination on the risk of postoperative recurrence of aortic dissection.Results Comparison of age,gender,history of smoking,history of drinking,history of diabetes,history of hypertension and Marfan syndrome between the recurrence group and non⁃recurrence group,the difference was not statistically significant(P>0.05).The proportion of individu⁃als in the recurrence group≥60 years old,combined Marfan syndrome and branch involvement>6 was higher than that in the non⁃recurrence group,and the difference was statistically significant(P<0.05).The levels of sICAM⁃3,ET⁃1,and sEng in the recurrence group were significantly higher than those in the non⁃recurrence group,and the differences were statistically significant(P<0.05).Logistic multivariate analysis showed that age≥60 years old,Marfan syndrome,the number of branches involved>6,sICAM⁃3,ET⁃1,and sEng levels were all increased risk factors for postoperative recurrence of aortic dissection(P<0.05).According to the ROC curve,the sensitivity and specificity of sICAM⁃3,ET⁃1,and sEng in predicting the risk of recurrence af⁃ter aortic dissection were 89.60％and 88.30％,respectively.The AUC was 0.872,which was higher than that of sICAM⁃3,ET⁃1,and sEng alone(P<0.05).Conclusion sICAM⁃3,ET⁃1 and sEng levels are highly ex⁃pressed in Stanford type B aortic dissection patients with postoperative recurrence.Preoperative monitoring of the changes of these indicators can effectively evaluate the recurrence risk of Stanford type B aortic dissection and provide a strong basis for formulating individualized treatment plans.
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