Predictive value of serum AFP,hCG and uE3 in pregnancy adverse events and fetal growth in patients with GDM during the second trimester
Objective To investigate the predictive value of serum alpha⁃fetoprotein(AFP),hu⁃man chorionic gonadotropin(hCG)and free estriol(uE3)in pregnancy adverse events and fetal growth in pa⁃tients with second trimester gestational diabetes mellitus(GDM).Methods A total of 117 GDM patients ad⁃mitted to the obstetrics Department of Xianning Central Hospital from January 2023 to May 2023 were selected and divided into a good outcome group(n=75)and a bad outcome group(n=42)based on the difference in pregnancy outcomes.According to the fetal growth and development,they were divided into a normal develop⁃ment group(n=89)and an abnormal development group(n=28).The relevant clinical data and laboratory indi⁃cators of each group were collected and compared.The risk factors affecting pregnancy adverse events and fetal growth and development in GDM patients were analyzed by multivariate logistic analysis,and the predictive ef⁃ficacy of serum AFP,hCG and uE3 in pregnancy adverse events and fetal growth and development in GDM pa⁃tients was analyzed by receiver operating characteristic curve(ROC).Results Multivariate logistic regression analysis showed that pre⁃pregnancy BMI≥24 kg/m2,increased AFP and hCG levels and decreased uE3 levels were independent risk factors for adverse pregnancy events in GDM patients(P<0.05).Pre⁃pregnancy BMI≥24 kg/m2,pregnancy number≥1,increased AFP,hCG levels and decreased uE3 level were independent risk factors for fetal growth and development in GDM patients(P<0.05).The ROC area of AFP,hCG and uE3 alone and in combination were 0.719,0.759,0.717 and 0.824 in GDM patients,respectively.The ROC area of fetal growth and development in GDM patients were 0.756,0.747,0.713 and 0.811 respectively(P<0.05).Conclusion Serum AFP,hCG and uE3 levels in the second trimester are closely associated with pregnancy ad⁃verse events and fetal growth and development in GDM patients,and the combined detection of the three has a higher predictive value for GDM pregnancy adverse events and fetal growth and development.
万方数据
维普
