The correlation between serum procalcitonin,gamma interferon,and C?reactive protein levels and the severity and prognosis of children with severe pneumonia
Objective To investigate the correlation of serum procalcitonin(PCT),gamma⁃inter⁃feron(IFN⁃γ)and C⁃reactive protein(CRP)with the severity of illness and prognosis of children with severe pneumonia(SP).Methods A total of 151 children with SP were admitted to Baoding Hospital of Beijing Chil⁃dren's Hospital,Capital Medical University from December 2021 to December 2022.They were selected as the severe pneumonia group.Additionally,150 patients with common pneumonia who were hospitalized during the same period were selected as the common pneumonia group,and 147 normal children who underwent physical examination in the outpatient department of the hospital were selected as the control group.The levels of serum PCT,IFN⁃γ,and CRP in the three groups were compared,and the levels of serum PCT,IFN⁃γ,and CRP in differ⁃ent prognosis of children with SP were compared.Pearson correlation analysis was used to analyze the correlation between serum PCT,IFN⁃γ,and CRP levels and pneumonia severity index(PSI).The predictive value of single and combined detection of PCT,IFN⁃γ,and CRP on the prognosis of children with SP was analyzed.Results The levels of PCT,IFN⁃γ and CRP in the three groups were compared as follows:severe pneumonia group>com⁃mon pneumonia group>control group.The difference was statistically significant(P<0.05).The follow⁃up showed that 41 cases had a good prognosis,and 110 cases had a poor prognosis.The levels of serum PCT,IFN⁃γ,and CRP in the poor prognosis group were higher than those in the good prognosis group,and the differences were statisti⁃cally significant(P<0.05).Pearson correlation analysis showed that serum PCT,IFN⁃γ,and CRP levels were posi⁃tively correlated with the expression of PSI scores(P<0.05).According to the ROC curve,the sensitivity and speci⁃ficity of combined detection of PCT,IFN⁃γ,and CRP in the prognosis of children with SP were 89.62％and 85.68％,respectively,and AUC=0.890,which was significantly higher than that of the three indicators alone(P<0.05).Conclusion Serum PCT,IFN⁃γ,and CRP levels are significantly correlated with the severity and progno⁃sis of SP children.These biomarkers can be detected to assess the severity of the disease and predict the prognosis of children,providing strong scientific support and references for formulating clinical treatment plans.
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