Research progress of epigenetic modification factors as biomarkers for early diagnosis and prognosis evaluation of pancreatic cancer
Pancreatic cancer is a highly malignant tumor of the digestive system with a poor prog-nosis.Researching sensitive and specific tumor markers for the early diagnosis and prognosis evaluation of pan-creatic cancer can improve survival rates.Advanced technologies have indicated that developing early diagnos-tic markers for pancreatic cancer would be more beneficial when considering epigenetic regulation.Epigenetic modification markers include DNA methylation,histone modification,non-coding RNA.In this study,we will explore the advantages of pancreatic cancer tissues,free circulating DNA in"liquid biopsy"samples,and epigenetic modification markers in exosomes for early diagnosis and prognosis evaluation of PDAC.We will also discuss limitations and future application prospects.
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