表观遗传修饰因子作为胰腺癌早期诊断与预后评估标志物的研究进展
Research progress of epigenetic modification factors as biomarkers for early diagnosis and prognosis evaluation of pancreatic cancer
王一然 1艾子译 1司文喆1
作者信息
- 1. 北京大学第三医院检验科,北京 100091
- 折叠
摘要
胰腺癌是一种恶性程度极高,预后极差的消化系统肿瘤,寻找灵敏、特异的肿瘤标志物应用于胰腺癌早期诊断及预后评估可以提高生存率.许多前沿性研究表明,从表观遗传调控的角度将更有助于胰腺癌早期诊断标志物的开发,潜在的表观遗传修饰标志物包括DNA甲基化、组蛋白修饰、非编码RNA等,本文对近年来基于胰腺癌组织及对"液体活检"样本中的游离循环DNA及外泌体中的表观遗传修饰标志物在早期诊断和预后评估中的优势、局限性和应用前景进行综述.
Abstract
Pancreatic cancer is a highly malignant tumor of the digestive system with a poor prog-nosis.Researching sensitive and specific tumor markers for the early diagnosis and prognosis evaluation of pan-creatic cancer can improve survival rates.Advanced technologies have indicated that developing early diagnos-tic markers for pancreatic cancer would be more beneficial when considering epigenetic regulation.Epigenetic modification markers include DNA methylation,histone modification,non-coding RNA.In this study,we will explore the advantages of pancreatic cancer tissues,free circulating DNA in"liquid biopsy"samples,and epigenetic modification markers in exosomes for early diagnosis and prognosis evaluation of PDAC.We will also discuss limitations and future application prospects.
关键词
胰腺癌/早期诊断/预后评估/表观遗传修饰/标志物Key words
Pancreatic cancer/Early diagnosis/Prognosis/Epigenetic modifications/Biomarker引用本文复制引用
出版年
2024
NETL
NSTL
万方数据