Effect of cyclophosphamide treatment of nephrotic syndrome on ApoA1,ApoB,and Lp(a)in patients
Objective To investigate the effects of treatment with cyclophosphamide combined with prednisone on renal function and serum apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),and li-poprotein(a)[Lp(a)]levels in patients with nephrotic syndrome.Methods 96 cases of patients with ne-phrotic syndrome admitted to Jinzhai County Traditional Chinese Medicine Hospital from January 2021 to Janu-ary 2024 were prospectively selected and divided into a control group(n=48)receiving prednisone acetate tab-lets alone,and a study group(n=48)receiving injectable cyclophosphamide in addition to prednisone acetate.The divison was done according to a randomized numerical table method.The dosage of the drug in both groups was adjusted based on the patients'adverse reactions and tolerance.Both groups received treatment for 12 months.The efficacy after 12 months of treatment,levels of inflammatory factors[interleukin(IL)-6,IL-8,tumor necrosis factor-alpha(TNF-α)],renal function indexes(urea nitrogen,serum creatinine,cystatin C),and ApoA1,ApoB,and Lp(a)levels(before and after 12 months of treatment)were compared between the two groups.Results Compared to the control group(72.92%),the study group had a higher overall remission rate after 12 months of treatment(89.58%),and this difference was statistically significant(P<0.05).Addition-ally,after 12 months of treatment,both groups showed a decrease in serum levels of IL-6,IL-8,TNF-α,urea nitrogen,creatinine,cystatin C,ApoA1,ApoB,and Lp(a)compared to pretreatment levels.The levels were lower in the study group than in the control group,and these differences were statistically significant(P<0.05).Conclusion The use of cyclophosphamide in combination with prednisone for treating patients with nephrotic syndrome can lower serum levels of ApoA1,ApoB,and Lp(a),improve lipid metabolism disorders,and re-duce inflammation and enhance renal function.This treatment has shown siginificant efficacy.
Nephrotic syndromeCyclophosphamidePrednisone acetateApolipoprotein A1Apolipoprotein BLipoprotein a
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