The predictive value and clinical significance of SAA,ACR and arteriosclerosis index in early renal damage in hypertension
Objective To investigate the predictive value and clinical significance of serum amy-loid A(SAA),urinary albumin to creatinine ratio(ACR)and arteriosclerosis index(AASI)in early renal damage in hypertension.Methods A total of 57 patients with uncomplicated hypertension admitted to Xingtai Central Hospital from May 2021 to May 2023 were selected as the control group,while 59 patients with hyper-tension and kidney damage were chosen as the observation group.The general data,SAA,ACR levels and AASI values of both groups were compared.Factors affecting renal damage in patients with hypertension were analyzed,and the predictive value of SAA,ACR,and AASI for renal damage in patients with hypertension was evaluated.Results The gender,age,presence of diabetes mellitus,smoking habits,body mass index,and fasting blood glucose levels between the two groups showed no statistically significant difference(P>0.05).However,there were statistically significant differences in hypertension grading and uric acid(UA)lev-els between the two groups(P<0.05).The SAA,ACR levels,and AASI values in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Logistic multivariate analysis showed that hypertension grade 3,UA>410 μmol/L,SAA>10 mg/L,ACR>30 mg and AASI<4 were related factors to early renal damage in patients with hypertension(P<0.05).The ROC results showed that the AUC of SAA,ACR,and AASI in predicting early renal damage in patients with hyper-tension was 0.894,which was higher than that of each individual index alone(P<0.05).Conclusion The de-tection of SAA,ACR,and AASI has important clinical significance in predicting early renal damage in hyper-tension.The combination of the three indicators has higher accuracy in predicting early renal damage in hyper-tension,providing a reliable reference for clinical diagnosis and treatment.
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