免疫功能检测在慢性乙型肝炎相关疾病中的临床价值
Clinical value of immune function detection in chronic hepatitis B-related diseases
张帆 1王雅杰2
作者信息
- 1. 首都医科大学附属北京地坛医院检验科,北京 100015;北京大学第一医院肾脏内科,北京 100034
- 2. 首都医科大学附属北京地坛医院检验科,北京 100015
- 折叠
摘要
目的 分析慢性乙型肝炎肝硬化代偿期与失代偿期患者的免疫功能检测指标,为肝硬化早期识别及病情监测治疗提供参考价值.方法 选择2021年10月至2023年1月在首都医科大学附属地坛医院住院患者肝硬化代偿期患者(LCC组)94例,肝硬化失代偿期患者(LCD组)96例,慢性乙型肝炎患者(CHB组)93例.检测外周血常用免疫指标及辅助T细胞功能.结果 LCD组血清IgA水平均高于LCC组,血清C1q、CD3+T细胞、CD8+T细胞、CD45+淋巴细胞水平低于LCC组,差异有统计学意义(P均<0.05),联合鉴别LCC组与LCD组的效果好,ROC曲线下面积(AUC)值为0.835,大于5项单一指标(P<0.05);CHB组血清IgA低于LCD组,血清C3、C4、C1q、CD3+T细胞、CD8+T细胞、CD4+T细胞、CD45+淋巴细胞高于LCD组,差异有统计学意义(P均<0.05),联合鉴别CHB组与LCD组的效果好,ROC曲线下面积(AUC)值为0.916,大于8项单一指标(P<0.05).结论 与CHB相比,CHB相关肝硬化失代偿期患者免疫指标水平存在明显差异.免疫指标联合检测有助于CHB相关疾病的早期识别及病情监测.
Abstract
Objective To analyze the immune function detection indexes of patients with compen-sated and decompensated chronic hepatitis B cirrhosis,and provide reference value for early dentification,dis-ease monitoring and treatment of cirrhosis.Methods Ninety-four patients with compensated cirrhosis,96 pa-tients with decompensated cirrhosis,and 93 patients with chronic hepatitis B were selected from Beijing Ditan Hospital,Capital Medical University from October 2021 to January 2023.The common immune indexes and helper T cell function in peripheral blood were measured.Results The serum IgA level in the LCD group was higher than that in the LCC group,and the levels of serum C1q,CD3+T cells,CD8+T cells,and CD45+lympho-cytes were lower than those in the LCC group.The differences were statistically significant(P<0.05).The com-bined effect of distinguishing the LCC group from the LCD group was significant.The area under the ROC curve(AUC)value was 0.835,which was higher than that of the five single indicators(P<0.05).The serum IgA level in the CHB group was lower than that in the LCD group,and the levels of serum C3,C4,C1q,CD3+T cells,CD8+T cells,CD4+T cells,and CD45+lymphocytes were higher than those in the LCD group.The differences were statistically significant(P<0.05).The combined effect of distinguishing the CHB group from the LCD group was significant,with an.area under the ROC curve(AUC)value of 0.916,which was higher than that of the eight single indicators(P<0.05).Conclusion Compared to CHB patients,there are clear differences in im-mune indicator levels among patients with decompensated CHB-related cirrhosis.The combined detection of im-mune indicators can be useful for early identification and monitoring of chronic hepatitis B-related diseases.
关键词
肝硬化/免疫指标/辅助T细胞功能/慢性乙型肝炎Key words
Cirrhosis/Immune indicators/Helper T cell function/Chronic hepatitis B引用本文复制引用
出版年
2024
NETL
NSTL
万方数据