Clinical value of immune function detection in chronic hepatitis B-related diseases
Objective To analyze the immune function detection indexes of patients with compen-sated and decompensated chronic hepatitis B cirrhosis,and provide reference value for early dentification,dis-ease monitoring and treatment of cirrhosis.Methods Ninety-four patients with compensated cirrhosis,96 pa-tients with decompensated cirrhosis,and 93 patients with chronic hepatitis B were selected from Beijing Ditan Hospital,Capital Medical University from October 2021 to January 2023.The common immune indexes and helper T cell function in peripheral blood were measured.Results The serum IgA level in the LCD group was higher than that in the LCC group,and the levels of serum C1q,CD3+T cells,CD8+T cells,and CD45+lympho-cytes were lower than those in the LCC group.The differences were statistically significant(P<0.05).The com-bined effect of distinguishing the LCC group from the LCD group was significant.The area under the ROC curve(AUC)value was 0.835,which was higher than that of the five single indicators(P<0.05).The serum IgA level in the CHB group was lower than that in the LCD group,and the levels of serum C3,C4,C1q,CD3+T cells,CD8+T cells,CD4+T cells,and CD45+lymphocytes were higher than those in the LCD group.The differences were statistically significant(P<0.05).The combined effect of distinguishing the CHB group from the LCD group was significant,with an.area under the ROC curve(AUC)value of 0.916,which was higher than that of the eight single indicators(P<0.05).Conclusion Compared to CHB patients,there are clear differences in im-mune indicator levels among patients with decompensated CHB-related cirrhosis.The combined detection of im-mune indicators can be useful for early identification and monitoring of chronic hepatitis B-related diseases.
CirrhosisImmune indicatorsHelper T cell functionChronic hepatitis B
NETL
NSTL
万方数据
