血清25-(OH)D、miR-26a、CTRP3水平与2型DM患者CIMT及CVD风险的相关性
Correlation of serum 25-(OH)D,miR-26a,and CTRP3 levels with CIMT and CVD risk in patients with type 2 DM
张玲霞 1彭婷瑜 1周纽纽 1张玲燕 1蔡潇潇1
作者信息
- 1. 南通市第六人民医院内分泌科,江苏,南通 226001
- 折叠
摘要
目的 探究血清25-羟基维生素D(25-(OH)D)、微小RNA(miR)-26a、补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)水平与2型糖尿病患者颈动脉内膜中层厚度(CIMT)及心血管疾病(CVD)风险的相关性.方法 选取2022年6月至2024年6月期间南通市第六人民医院收治的112例2型糖尿病患者作为研究对象,根据心血管疾病风险等级分为低风险组(28 例)、中风险组(39 例)和高风险组(45 例).比较3组间血清25-(OH)D、miR-26a和CTRP3水平的差异,采用斯皮尔曼相关性分析及多元logistics回归分析以上指标与 2 型糖尿病患者CIMT和CVD风险的相关性.结果 3 组性别相比较,差异无统计学意义(P>0.05).3组的年龄和CIMT比较结果:低风险组<中风险组<高风险组,差异有统计学意义(P<0.05).血清 25-(OH)D、miR-26a和CTRP3水平比较:低风险组>中风险组>高风险组,差异有统计学意义(P<0.05).斯皮尔曼相关性分析和多元logistics回归分析结果显示,血清 25-(OH)D、miR-26a和CTRP3 水平均与 2 型糖尿病患者CIMT和CVD风险成负相关,差异具有统计学意义(P<0.05).结论 血清25-(OH)D、miR-26a和CTRP3水平与2型糖尿病患者CIMT和CVD风险具有一定的相关性,可作为临床提示2型糖尿病患者发生心血管疾病的辅助指标.
Abstract
O4bjective To investigate the correlation between serum 25-hydroxy vitamin D(25-(OH)D),microRNA(miR)-26a,and complement C1q/tumor necrosis factor-related protein 3(CTRP3)lev-els and carotid intima-media thickness(CIMT)and cardiovascular disease(CVD)risk in patients with type 2 diabetes.Methods A total of 112 patients with type 2 diabetes admitted to the Sixth People's Hospital of Nan-tong between June 2022 and June 2024 were selected as the study subjects.They were divided into three groups based on their risk class of cardiovascular disease:a low-risk group(28 patients),an intermediate-risk group(39 patients),and a high-risk group(45 patients).Differences in serum 25-(OH)D,miR-26a,and CTRP3 levels were compared among the 3 groups.The correlation between the above indicators and the risk of CIMT and CVD in patients with type 2 diabetes mellitus was analyzed using Spearman correlation analysis and multi-variate logistic regression.Results Compared to the gender of the 3 groups,the difference was not statisti-cally significant(P>0.05).when comparing the age and CIMT in the 3 groups,there was a statistically signifi-cant difference,with the low-risk group<intermediate-risk group<high-risk group(P<0.05).The comparison of serum 25-(OH)D,miR-26a,and CTRP3 levels among the 3 groups showed that the low-risk group>inter-mediate-risk group>high-risk group,and the differences were statistically significant(P<0.05).The results of Spearman correlation analysis and multivariate logistic regression analysis indicated that serum 25-(OH)D,miR-26a,and CTRP3 levels were all negatively correlated with the risk of CIMT and CVD in patients with type 2 diabetes mellitus,and the differences were statistically significant(P<0.05).Conclusion Serum 25-(OH)D,miR-26a,and CTRP3 levels are correlated with CIMT and CVD risk in patients with type 2 diabetes mellitus.They can be used as auxiliary indicators to clinically suggest the occurrence of cardiovascular disease in patients with type 2 diabetes mellitus.
关键词
25-羟基维生素D/微小RNA-26a/补体C1q/肿瘤坏死因子相关蛋白3/2型糖尿病/颈动脉内膜中层厚度/心血管疾病Key words
25-(OH)D/MicroRNA-26a/CTRP3/Type 2 diabetes mellitus/Carotid intima-me-dia thickness/Cardiovascular disease引用本文复制引用
出版年
2024
NETL
NSTL
万方数据