The value of serum thyroid hormone,EOS and GDF-15 levels in evaluating the prognosis of AECOPD patients
Objective To investigate the prognostic value of serum thyroid hormone,eosinophil(EOS)and growth differentiation factor-15(GDF-15)level tests in assessing the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 117 patients with AECOPD admitted to Zhengzhou First People's Hospital from July 2019 to December 2023 were selected as the study subjects.The prognosis of AECOPD patients was statistically analyzed.The general data of the good prognosis group and the poor prognosis group were compared.The levels of serum thyroid hormone,EOS and GDF-15 were compared between the two groups.The multiple factors affecting the prognosis of AECOPD patients were analyzed.The value of thyroid hormone,EOS and GDF-15 alone and in combination in evaluating the prognosis of AECOPD patients was analyzed.Results After 10 days of treatment,patients were divided into two groups based on their prognosis:the poor prognosis group(44 cases)and the good prog-nosis group(73 cases).A comparison of gender,age,smoking history,duration of mechanical ventilation,duration of hormone uses and duration of COPD between the two groups showed no statistically significant dif-ference(P>0.05).However,a comparison of CRP,FEV1,and FEV1/FVC between the two groups revealed statistically significant differences(P<0.05).The levels of T3,FT3 and EOS in the poor prognosis group were lower than those in the good prognosis group,and the level of GDF-15 was higher than that in the good prog-nosis group,the differences were statistically significant(P<0.05).Binary logistic regression analysis showed that CRP>10 mg/L,T3<1.34,>2.73 nmol/L,FT3<3.1,>6.8/L,EOS 0.5-5%,and GDF-15>1200 levels were the risk factors affecting the prognosis of AECOPD(P<0.05).The AUC of T3,FT3,EOS,and GDF-15 combined to predict prognosis in AECOPD patients was 0.894,which was higher than that of T3,FT3,EOS,and GDF-15 alone(P<0.05).Conclusion The levels of T3,FT3,EOS,and GDF-15 hold significant value in the prognosis evaluation of AECOPD.They can provide a basis for the clinical formulation of a more accu-rate and individualized treatment plan.
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