Predictive value of serum sTREM-1,adiponectin and PLR for VAP in patients undergoing mechanical ventilation after traumatic brain injury surgery
Objective To analyze the predictive value of serum soluble triggering receptor ex-pressed on myeloid cells-1(sTREM-1),adiponectin(ADPN)and platelet to lymphocyte ratio(PLR)for ven-tilator-associated pneumonia(VAP)in patients undergoing mechanical ventilation after surgery for traumatic brain injury.Methods A total of 96 patients who underwent surgery for traumatic brain injury at the First Hospital of Jilin University from April 2022 to December 2023 and received mechanical ventilation were se-lected.Upon admission,serum levels of sTREM-1,ADPN,and PLR were measured in all patients.The petients were then divided into two groups based on the presence or absence of VAP:the VAP group(n=33)and the non-VAP group(n=63).The risk factors for VAP were analyzed,and receiver operating characteristic(ROC)curves were used to assess the predictive value of serum sTREM-1,ADPN,and PLR for VAP.Results Serum sTREM-1 and PLR levels in the VAP group were higher than those in the non-VAP group,while ADPN levels were lower than those in the non-VAP group(P<0.05).Results from multivariate logistic regression analysis results indicated that elevated serum sTREM-1 and PLR levels were risk factors for VAP in patients undergoing mechanical ventilation after surgery for traumatic brain injury,whereas elevated ADPN levels were protective factors(P<0.05).The combination of sTREM-1,ADPN,and PLR had an AUC of 0.921,sensitivity of 0.903,and specificity of 0.938 for predicting VAP,all of which were higher than those of using a single indicator(P<0.05).Conclusion Abnormal serum sTREM-1,ADPN,and PLR are factors that influence the occurrence of VAP in patients undergoing mechanical ventilation after surgery for traumatic brain injury.These three factors can assist in diagnosing VAP in patients following surgery for traumatic brain injury who require mechanical ventilation.
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