Changes in serum levels of IL-6,TNF-α and NO in the ascending sequence of great saphe-nous vein grafts during off-pump bypass and their relationship with patency rate
Objective To investigate the changes of serum interleukin-6(IL-6),tumor necrosis fac-tor-α(TNF-α)and nitric oxide(NO)levels in the ascending sequence of great saphenous vein grafts in off-pump bypass grafting(OPCAB)and their relationship with patency rate.Methods From January 2019 to June 2022,262 patients whon underwent OPCAB at the Seventh People's Hospital of Zhengzhou were selected as the re-search subjects.The levels of IL-6,TNF-α,and NO at different time points in patients undergoing OPCAB were compared.Using the Fitzgibbon standard,the patency of bridge vessels after the operation was assessed.Single factors and risk factors influencing the patency of bridge vessels post-operation were analyzed.The impact of IL-6,TNF-α,NO,both individual and in combination,on predicting postoperative graft patency was evaluated.Results The levels of IL-6,TNF-α,and NO from low to high were as follows:preoperative<postoperative 6 h<postoperative immediately,and the difference was statistically significant(P<0.05).Out of the 262 pa-tients,172(65.65%)had unobstructed grafts after OPCAB,while 90(34.35%)had obstructed grafts.The unob-structed group had fewer bypass vessels,less postoperative recurrent angina pectoris,and fewer cases of preop-erative old myocardial infarction compared to the obstructed group.Additionally,the levels of IL-6,TNF-α,and NO were lower in the unobstructed group,with statistically significant differences(P<0.05).Binary logistic regression analysis revealed that an increase in the number of bypass vessels,elevated levels of IL-6 and TNF-α,and a decrease in NO levels were the risk factors affecting graft patency after OPCAB(P<0.05).The AUC of combined detection of IL-6,TNF-α,and NO in predicting the patency of grafts after OPCAB was 0.865,which was higher than that of the three individual indicators alone(P<0.05).Conclusion Abnormal changes in the ex-pression levels of IL-6,TNF-α,and NO occur in the great saphenous vein grafts during the retrograde sequence of off-pump bypass.The combined detection of these three indicators can effectively predict the patency of the graft after OPCAB,providing strong support for clinical evaluation of patient prognosis.
NETL
NSTL
万方数据
