Relationship between ApoB,ApoA1 and their ratio and microvascular complications in pa-tients with type 2 diabetes
Objective To investigate the relationship between apolipoprotein B(ApoB),Apoli-poprotein A1(ApoA1)and their ratio and microvascular complications in patients with type 2 diabetes melli-tus(T2DM).Methods 110 T2DM patients admitted to our hospital from January 2021 to December 2023 were selected as the subjects of this study.They were divided into two groups:the complication group(47 cases)and the simple T2DM group(63 cases)based on whether microvascular complications occurred.In ad-dition,150 healthy individuals who underwent physical examinations in our hospital during the same period were chosen as the control group.Serum levels of ApoB and ApoA1 and the ApoB/ApoA1 ratio were com-pared among the three groups.The predictive value of ApoB,ApoA1 and the ApoB/ApoA1 ratio for microvas-cular complications in T2DM patients was evaluated using ROC analysis.Factors influencing microvascular complications in T2DM patients were assessed through binary logistic stepwise regression.Results Serum ApoB levels and the ApoB/ApoA1 ratio were found to be orders of:control group<simple T2DM group<com-plication group,while serum ApoA1 level:control group>simple T2DM group>complication group(P<0.05).The area under the curve(AUC)95%confidence interval(CI)of ApoB,ApoA1 and the ApoB/ApoA1 ratio for predicting microvascular complications in T2DM patients were 0.744(0.692～0.796),0.862(0.810～0.914)and 0.901(0.849～0.953).The proportion of complications combined with hypertension,the proportion of T2DM duration≥10 years,fasting blood glucose,HbAlc,HOMA-IR,total cholesterol and se-rum creatinine were higher than those of the T2DM group alone(P<0.05).A long course of T2DM disease,high level of HOMA-IR and high level of HbAlc and elevated ApoB/ApoA1 ratio were independent risk factors for microvascular complications in T2DM patients(P<0.05).Conclusion The ApoB/ApoA1 ratio is more effective in predicting microvascular complications in T2DM patients than using serum ApoB and ApoA1 as individual factor.Monitoring changes of the ApoB/ApoA1 ratio can offer guidance for clinical treatment.
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