Efficacy of ulinastatin combined with norepinephrine bitartrate on septic shock and its in-fluence on liver-kidney function
Objective To explore the effect of ulinastatin(UTI)combined with norepinephrine bitartrate in the treatment of septic shock and its influence on liver-kidney function.Methods The clinical data of 54 patients with septic shock at Anqing Municipal Hospital from January 2021 to January 2024 were ret-rospectively analyzed.The patients were divided into a control group(n=25)and a combined treatment group(n=29)based on different treatment regimens.All patients received basic treatments including fluid resuscita-tion,electrolyte regulation,antibacterial therapy,respiratory support and nutritional support.In addition to the basic treatments,the control group received norepinephrine bitartrate,while the combined treatment group was treated with UTI injection in addition to norepinephrine bitartrate.The therapeutic effect after 1 week of treat-ment,changes in heart rate(HR)and mean arterial pressure(MAP)within 24 hours of treatment and changes in inflammatory marks[C-reactive protein(CRP),interleukin-1β(IL-1β),tumor necrosis factor(TNF)],liver function indicators[serum total bilirubin(TBil),γ-glutamyl transpeptidase(γ-GT)and aspartate amino-transferase(AST)]and renal function indicators[blood urea nitrogen(BUN),serum creatinine(Scr)and uri-nary acid(UA)]before and after treatment were compared between both groups.The prognosis of the two groups was statistically analyzed.Results The total effective rate of treatment in the combined treatment group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).As the treatment time increased,HR in both groups decreased gradually while MAP increased gradually.The HR in the combined treatment group was lower than that in the control group,and the MAP was higher than that in the control group,and the difference was statistically significant(P<0.05).After treat-ment,the levels of inflammatory markers(CRP,IL-1β and TNF),liver function indicators(TBil,γ-GT and AST)and renal function indicators(BUN,Scr and UA)were significantly reduced in both groups.The levels in the combined treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in adverse reactions between the two groups(P>0.05).The 28-day mortality rate in the combined treatment group was significantly lower compared to the con-trol group,and the difference was statistically significant(P<0.05).Conclusion The combination of UTI and norepinephrine bitartrate is effective in treating septic shock.This treatment can improve liver and kidney function,reduce inflammation levels,and has few adverse reactions.
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