摘要
目的 探讨宫颈癌组织中叶酸受体1(FOLR1)、间皮素(MSLN)表达及其与临床病理特征的关系.方法 选取2022年1月至2023年1月秦皇岛市第一医院收治的80例宫颈癌患者作为研究对象,采用免疫组化方法检测宫颈癌组织及其癌旁组织中FOLR1、MSLN的表达情况,并分析宫颈癌组织中FOLR1、MSLN表达与临床病理特征的关系;根据患者术后1年复发情况分为复发组和非复发组,比较两组临床资料,采用多因素回归分析宫颈癌患者术后复发的影响因素.结果 宫颈癌组织中FOLR1、MSLN阳性表达高于癌旁组织,差异有统计学意义(P<0.05);病理类型为鳞癌、中低分化、FIGO分期Ⅱa期、有淋巴结转移的宫颈癌患者FOLR1和MSLN表达高于病理类型为腺癌、高分化、FIGO分期Ⅰa+Ⅰb期、无淋巴结转移的患者,差异有统计学意义(P<0.05);随访1年,22例患者发生复发.复发组和非复发组病理类型、分化程度、FIGO分期、淋巴结转移、FOLR1表达、MSLN表达比较差异具有统计学意义(P<0.05);采用二元Logistic分析,中+低分化、淋巴结转移、FOLR1表达阳性、MSLN表达阳性均为影响宫颈癌患者术后复发的独立危险因素(P<0.05).结论 宫颈癌组织中FOLR1、MSLN阳性表达升高,且与患者临床病理特征密切相关,二指标可为预测术后复发提供参考.
Abstract
Objective To explore the expressions of folate receptor 1(FOLR1)and mesothelin(MSLN)in cervical cancer tissues and their relationship with clinicopathological characteristics.Methods A total of 80 patients with cervical cancer were admitted to the First Hospital of Qinhuandao and enrolled as re-search subjects between January 2022 and January 2023.The expressions of FOLR1 and MSLN in cervical can-cer tissues and para-carcinoma tissues were detected using immunohistochemistry,and the relationship be-tween FOLR1 and MSLN in cervical cancer tissues and clinicopathological characteristics was analyzed.Based on the presence or absence of recurrence at 1 year after surgery,patients were divided into a recurrence group and a non-recurrence group.The clinical data in the two groups were compared.The influencing factors of post-operative recurrence in patients with cervical cancer were analyzed using multivariate regression analysis.Results The positive expressions of FOLR1 and MSLN in cervical cancer tissues were higher than those in para-carcinoma tissues(P<0.05).The expressions of FOLR1 and MSLN in cervical cancer patients with patho-logical type of squamous cell carcinoma,moderate to low differentiation,FIGO stage Ⅱa,and lymph node metastasis were higher than those in patients with pathological type of adenocarcinoma,highly differentiated,FIGO stageⅠa+Ⅰb,and no lymph node metastasis(P<0.05).After 1 year of follow-up,there were 21 cases with recurrence.There were significant differences in pathological types,differentiation degree,FIGO stag-ing,lymph node metastasis,expressions of FOLR1 and MSLN between the recurrence group and non-recur-rence group(P<0.05).Binary logistic analysis revealed that high differentiation,lymph node metastasis,and positive expressions of FOLR1 and MSLN were independent risk factors for postoperative recurrence in pa-tients with cervical cancer(P<0.05).Conclusion The levels of FOLR1 and MSLN expression in cervical cancer tissues are elevated.These two indicators are closely related to clinicopathological characteristics of pa-tients,and can be used as a reference for predicting postoperative recurrence.
NETL
NSTL
万方数据