Influence of Qili Qiangxin capsule on intestinal flora,plasma TNF-α,IL-Iβ,H-FABP and TMAO levels and cardiac function in patients with chronic heart failure
Objective To evaluate the influence of Qili Qiangxin capsule on intestinal flora,lev-els of tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-Iβ),heart-type fatty acid binding protein(H-FABP)and trimethylamine N-oxide(TMAO)and cardiac function in patients with chronic heart failure(CHF).Methods From July 2021 to July 2023,198 patients with CHF at Zibo Hospital of Traditional Chi-nese Medicine were selected and randomized into two groups:the Western medicine group and the Qili Qiangxin group,with 99 cases in each group.The Western medicine group received routine western medicine treatment,while the Qili Qiangxin group received Qili Qiangxin capsules in addition to the routine treatment.Both groups underwent an 8-week treatment period.Before and after treatment,symptoms,intestinal flora and levels of serum TNF-α,IL-Iβ,H-FABP,B-type natriuretic peptide(BNP),N-terminal pro-B-type natriuretic peptide(NT-proBNP),and TMAO were compared between groups.The left ventricular ejection fraction(LVEF)was measured,and the 6-minute walking test(6MWT)was used to evaluate exercise tolerance.Ad-verse reactions were aslo recorded.Results After 8 weeks of treatment,the syndrome scores in the Qili Qiangxin group were significantly lower than those in the Western medicine group(P<0.05).The counts of Bi-fidobacterium,Lactobacillus and Bacteroides in the Qili Qiangxin group were higher than those in the Western medicine group,while the counts of Escherichia coli and yeast were significantly lower than those in the West-ern medicine group(P<0.05).The levels of TNF-α,IL-Iβ,and TMAO in the Qili Qiangxin group were sig-nificantly lower than those in the Western medicine group(P<0.05).The levels of LVEF and 6MWT in the Qili Qiangxin group were significantly higher,while the levels of H-FABP,BNP,and NT-proBNP were sig-nificantly lower compared to the Western medicine group(P<0.05).Furthermore,there were no statistical dif-ferences in toxic and side effects between the groups(P>0.05).Conclusion Qili Qiangxin capsule can sig-nificantly improve the intestinal microecology,inflammation and cardiac function of patients with heart fail-ure,making it clinically valuable.
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