The prognosis of Aidi injection in the treatment of advanced gastric cancer and its relation-ship with the expression of peripheral blood lncRNA ZNF667-AS1 and miR-126
Objective To investigate the prognosis of patients with advanced gastric cancer treated with Aidi injection and its relationship with the expression of lncRNA ZNF667-AS1,miR-126 in periph-eral blood.Methods 60 patients with advanced gastric cancer who received treatment at our hospital from January 2022 to March 2023 were included in this study.Levels of lncRNA ZNF667-AS1 and miR-126 in pe-ripheral blood were measured on the day of admission.All patients underwent chemoradiation and chemo-therapy in combination with Aidi injection.Based on the survival outcomes during a 1-year follow-up,patients were divied into a group with a good prognosis(n=44)and a group with a poor prognosis group(n=16).Gen-eral data and the expression levels of lncRNA ZNF667-AS1and miR-126 in peripheral blood were compared be-tween the two groups.The relationship between the expression levels of lncRNA ZNF667-AS1,miR-126 in pe-ripheral blood,and the prognosis of patients with advanced gastric cancer treated with Aidi injection was ana-lyzed.The aim was to evaluate the prognostic value of lncRNA ZNF667-AS1 and miR-126 expression levels in peripheral blood in patients with advanced gastric cancer receiving Aidi injection treatment.Results In a study of 60 patients with advanced gastric cancer,16 cases(26.67%)had a poor prognosis,while 44 cases(73.33%)had a good prognosis.The expression levels of lncRNA ZNF667-AS1and miR-126 in the peripheral blood of the poor prognosis group were lower than those in the good prognosis group,with statistical signifi-cance(P<0.05).Logistic regression analysis showed that abnormal low expression of lncRNA ZNF667-AS1and miR-126 in peripheral blood were independent risk factors for poor prognosis in patients with advanced gastric cancer(OR>1,P<0.05).The ROC curve showed that the AUC of peripheral bloodlncRNA ZNF667-AS1+miR-126 in predicting the prognosis of patients with advanced gastric cancer treated with Aidi injection was 0.924,with a sensitivity of 0.902 and specificity of 0.836.Conclusion Low expression of lncRNA ZNF667-AS1 and miR-126 in peripheral blood is associated with a poor prognosis in patients with advanced gastric cancer who are treated with Aidi injection.
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