Efficacy of Lactobacillus in the treatment of peri-implant disease and its effect on Porphy-romonas gingivalis
Objective To investigate the effect of probiotics on periodontal health,periodontal pathogens in saliva and inflammatory factors in gingival crevicular fluid.Methods A total of 58 patients with implant mucositis and 60 patients with peri-implant inflammation were admitted to the Stomatology Depart-ment of Cangzhou People's Hospital from January 2021 to December 2023.They were randomly divided into two groups:the treatment group for implant mucositis with 29 patients,and the control group with the same number of patients.Similarly,the treatment group for peri-implant inflammation consisted of 30 patients,with a corresponding control group.All patients reveived basic periodontal basic treatment,with the treatment group also receiveing additional lactobacillus probiotic combined treatment.The clinical efficacy,periodontal in-dexes[periodontal pocket depth(PD),gingival bleeding index(BI)],inflammatory factors in gingival cre-val fluid[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]and the pathogenic bacteria porphyromonas gingivalis in saliva were compared before and after treatment in different groups.Results Compared to before treatment,the concentrations of PD,BI,TNF-α,hs-CRP,and Porphyromonas gingivalis in saliva were all desreased at 4 and 12 weeks after treatment for graft mucositis.Additionally,these indicators in the treatment group were lower than those in the control group.The difference was statistically sig-nificant(P<0.05).The concentrations of PD,BI,TNF-α,hs-CRP,and Porphyromonas gingivalis in saliva also decreased at 4 and 12 weeks after treatment for periphytitis,with the treatment group showing lower levels than the control group,and with statistically significant differences(P<0.05).The clinical effectiveness of the treatment groups for graft mucositis and periphytitis was higher than that of the control group,and the differ-ence was statistically significant(P<0.05).Conclusion Probiotics can effectively improve periodontal condi-tions by reducing periodontal pathogens in saliva and inflammatory factors in gingival crevicular fluid.The clinical effects are positive.
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