MLR in evaluating the short-term efficacy of sublingual immunotherapy in children with allergic rhinitis
Objective To investigate the value of monocyte/lymphocyte ratio(MLR)in evaluat-ing the short-term efficacy of sublingual immunotherapy in children with allergic rhinitis(AR).Methods A total of 87 children with AR from August 2020 to July 2023 were selected for the AR group,then divided into a clinical response group(n=59)and a non-response group(n=28)based on short-term efficacy.In addition,110 healthy children who had undergone physical examinations were chosen as the control group.The levels of peripheral blood mononuclear cells(MN),lymphocytes(LYM),and MLR were compared between the AR group and the control group,as well as between the clinical response group and the non-response group.The predictive value of MN,LYM,and MLR in peripheral blood for the short-term efficacy of sublingual immuno-therapy in children with AR was assessed using ROC analysis.Multivariate logistic regression analysis was con-ducted to explore the factors related to the short-term efficacy of sublingual immunotherapy in children with AR.Results The levels of MN and MLR in the peripheral blood of the AR group were higher compared to the control group,while the levels of LYM in the peripheral blood were lower compared to the control group(P<0.05).The levels of MN and MLR in the non-response group were higher compared to the clinical re-sponse group,and the levels of LYM were lower compared to the clinical response group(P<0.05).The area under the curve(AUC)of peripheral blood MN,LYM,and MLR in predicting the short-term efficacy of sub-lingual immunotherapy in children with were 0.905,respectively.TNSS score,TMS score and MLR were the factors that affected the short-term efficacy of sublingual immunotherapy in children with AR(P<0.05).Con-clusion The increase in MLR levels is correlated with the short-term efficacy of sublingual immunotherapy in children with AR,making it an important marker for predicting the treatment's effectiveness in this population.
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